SCHEMBL1555099

SCHEMBL1555099

COc1ccc(C(=O)Cl)c(F)c1

nearest known ligand 0.61

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CPS1 P31327 15/20 0.61
HPGD P15428 3/20 0.50
ALDH1A1 P00352 3/20 0.50
MEN1 O00255 2/20 0.50
LMNA P02545 2/20 0.50
KMT2A Q03164 2/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
GAA P10253 1/20 0.50
ALOX12 P18054 1/20 0.50
CYP3A4 P08684 1/20 0.49
MAPK1 P28482 1/20 0.49
ALOX15 P16050 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylformamide SCHEMBL27707831 0.89 CPS1 (0.51) CPS1HPGDALDH1A1MEN1LMNA
SCHEMBL24338 0.85 CPS1 (0.49) CPS1HPGDALDH1A1MEN1LMNA
SCHEMBL531399 0.83 ALDH1A1 (0.65) CPS1HPGDALDH1A1MEN1LMNA
SCHEMBL1051747 0.83 CPS1 (0.63) CPS1HPGDALDH1A1MEN1LMNA
SCHEMBL29639738 0.83 ALDH1A1 (0.65) CPS1HPGDALDH1A1MEN1LMNA
SCHEMBL11197823 0.82 NPC1 (0.55) CPS1HPGDALDH1A1LMNANPC1
SCHEMBL312364 0.82 KDM4E (0.51) CPS1ALDH1A1MEN1LMNAKMT2A
SCHEMBL72082 0.81 CPS1 (0.61) CPS1HPGDALDH1A1MEN1LMNA
SCHEMBL15226106 0.81 CPS1 (0.61) CPS1HPGDALDH1A1MEN1LMNA
SCHEMBL1554929 0.81 CPS1 (0.61) CPS1HPGDALDH1A1MEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 133 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4713306-A1 NOVEL TRACER FOR THE IN VIVO DETECTION OF THE AGGREGATION OF ALPHA-SYNUCLEIN Stichting Amsterdam UMC (NL) 2026-03-25 EP disclosed
EP-4662209-A1 CONJUGATE COMPOUNDS AND COMPOSITIONS Rezubio Pharmaceuticals Co., Ltd (CN) 2025-12-17 EP disclosed
US-20250223281-A1 ANTIDIABETIC COMPOUNDS AND COMPOSITIONS REZUBIO PHARMACEUTICALS CO., LTD (CN) 2025-07-10 US disclosed
EP-3728234-B1 RADIOLABELED COMPOUNDS HOFFMANN LA ROCHE (CH) 2025-05-14 EP disclosed
US-20250073338-A1 CONJUGATE COMPOUNDS AND COMPOSITIONS REZUBIO PHARMACEUTICALS CO., LTD (CN) 2025-03-06 US disclosed
WO-2024236054-A1 NOVEL TRACER FOR THE IN VIVO DETECTION OF THE AGGREGATION OF ALPHA-SYNUCLEIN Stichting Amsterdam UMC (NL) 2024-11-21 WO disclosed
EP-4463451-A1 ANTIDIABETIC COMPOUNDS AND COMPOSITIONS Rezubio Pharmaceuticals Co., Ltd (CN) 2024-11-20 EP disclosed
CN-118829638-A Coupling compounds and compositions 宁康瑞珠生物制药(珠海)有限公司 2024-10-22 CN disclosed
CN-118724796-A Phenylpropionic acid derivative, and preparation method and application thereof 广东众生睿创生物科技有限公司 2024-10-01 CN disclosed
CN-118619932-A GPR40 agonist and preparation method and application thereof 广东众生睿创生物科技有限公司 2024-09-10 CN disclosed
EP-0833820-B1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS AVENTIS PHARMA INC (US) 2001-02-14 EP disclosed
US-6166072-A Amino acid derivatives ALLELIX NEUROSCIENCE, INC. (CA) 2000-12-26 US disclosed
US-6008348-A TREATING A 1-TOSYLATED INDAZOL-3-YL PIPERAZINE DERIVATIVE WITH CONCENTRATED HYDROCHLORIC ACID TO PRODUCE THE DETOSYLATED INDAZOL-3-YL PIPERAZINE COMPOUND OF GIVEN FORMULA HOECHST MARION ROUSSEL, INC. (US) 1999-12-28 US disclosed
US-5965554-A PIPERAZINYLBENZISOXAZOLE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1999-10-12 US disclosed
WO-1999034790-A1 GLYCINE TRANSPORT INHIBITORS ALLELIX NEUROSCIENCE, INC. (US) 1999-07-15 WO disclosed
US-5852022-A Antipsychotic agents, composition and method of use HOECHST ROUSSEL PHARMACEUTICALS INC. (US) 1998-12-22 US disclosed
CN-1187192-A Benzisoxazole and indazole derivatives as antipsychotic agents HOECHST MARION ROUSSEL INC (US) 1998-07-08 CN disclosed
EP-0833820-A1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 1998-04-08 EP disclosed
US-5696113-A Antipsychotic agents, compositions and method of use HOECHST MARION ROUSSEL, INC. (US) 1997-12-09 US disclosed
WO-1996039397-A1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 1996-12-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250223281-A1 ANTIDIABETIC COMPOUNDS AND COMPOSITIONS GPR119, GLP1R, GPR65 CPS1 3641/4885HPGD 2699/4885ALDH1A1 2556/4885
US-20250073338-A1 CONJUGATE COMPOUNDS AND COMPOSITIONS GPR119, GPR65, GPR55 CPS1 3778/4885HPGD 2084/4885ALDH1A1 1802/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.