Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 3/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15564219 | 1.00 | SCN5A (0.44) | SCN5ASCN9AKDM4ECTDSP1KCNH2 | |
| SCHEMBL18248486 | 0.83 | CHRM3 (0.54) | SCN5ASCN9AKDM4ECTDSP1KCNH2 | |
| SCHEMBL18248596 | 0.83 | CHRM3 (0.54) | SCN5ASCN9AKDM4ECTDSP1KCNH2 | |
| SCHEMBL7643094 | 0.83 | CHRM3 (0.54) | SCN5ASCN9AKDM4ECTDSP1KCNH2 | |
| SCHEMBL15564307 | 0.81 | SCN5A (0.40) | SCN5ASCN9AOPRK1CYP3A4LMNA | |
| SCHEMBL15564311 | 0.80 | FAAH (0.40) | SCN5ASCN9AOPRK1CYP3A4TDP1 | |
| SCHEMBL9030777 | 0.79 | PPARG (0.42) | KDM4EKCNH2OPRK1CYP3A4SLC22A2 | |
| Phosphoric Acid SCHEMBL3688742 | 0.78 | CHRM2 (0.49) | SCN5ASCN9AKDM4ECTDSP1KCNH2 | |
| Phosphoric Acid SCHEMBL29728497 | 0.78 | CHRM2 (0.49) | SCN5ASCN9AKDM4ECTDSP1KCNH2 | |
| SCHEMBL2073778 | 0.77 | CYP3A4 (0.43) | SCN5ASCN9AKDM4ECTDSP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882724-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - Science Park S.p.A. (IT) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014023754-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF DISORDERS THAT ARE AMELIORATED BY INHIBITION OF HDAC | IRBM - SCIENCE PARK S.P.A. (IT) | 2014-02-13 | — | — | WO | disclosed |