Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 11/20 | 0.72 |
| ▸ | MAPT | P10636 | 8/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | PDE6D | O43924 | 1/20 | 0.62 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.62 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15568058 | 0.83 | TP53 (0.63) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL15568494 | 0.82 | TP53 (0.59) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL15568359 | 0.79 | TP53 (0.76) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL15063430 | 0.79 | TP53 (0.87) | TP53MAPTSMN1; SMN2 | |
| SCHEMBL29412044 | 0.79 | TP53 (1.00) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL28227635 | 0.79 | TP53 (0.69) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL229828 | 0.78 | ALDH1A1 (1.00) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL29412062 | 0.78 | TP53 (0.78) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL15568102 | 0.77 | TP53 (0.76) | TP53MAPTALDH1A1PDE6DALDH2 | |
| SCHEMBL15673535 | 0.76 | LMNA (0.72) | TP53MAPTALDH1A1PDE6DALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | claimed |
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | disclosed |