Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 7/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | PDE6D | O43924 | 1/20 | 0.59 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.59 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.59 |
| ▸ | CFTR | P13569 | 1/20 | 0.58 |
| ▸ | GALR3 | O60755 | 1/20 | 0.55 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28227656 | 0.87 | MAPT (0.77) | MAPTLMNATP53TSHRHSD17B10 | |
| SCHEMBL28261635 | 0.84 | ALDH1A1 (0.72) | MAPTLMNATP53TSHRALDH1A1 | |
| SCHEMBL30934017 | 0.79 | MAPT (0.80) | MAPTLMNATP53TSHRHSD17B10 | |
| SCHEMBL15474874 | 0.79 | LMNA (0.65) | MAPTLMNATP53TSHRALDH1A1 | |
| SCHEMBL29076181 | 0.79 | MAPT (0.67) | MAPTLMNATP53TSHRHSD17B10 | |
| SCHEMBL30581242 | 0.79 | MAPT (0.67) | MAPTLMNATP53TSHRHSD17B10 | |
| SCHEMBL26350322 | 0.78 | LMNA (0.63) | MAPTLMNATP53TSHRALDH1A1 | |
| SCHEMBL8881382 | 0.77 | RAB9A (0.65) | MAPTLMNATP53TSHRALDH1A1 | |
| SCHEMBL8305154 | 0.77 | HDAC1 (0.71) | MAPTLMNATP53ALDH1A1PDE6D | |
| SCHEMBL8305149 | 0.77 | HDAC1 (0.85) | MAPTLMNAHDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | disclosed |