Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 4/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.41 |
| ▸ | ORAI2 | Q96SN7 | 3/20 | 0.41 |
| ▸ | ORAI3 | Q9BRQ5 | 3/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | MGLL | Q99685 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28745155 | 0.82 | TRPV6 (0.37) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL1429795 | 0.79 | TRPV6 (0.41) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL15570627 | 0.78 | TRPV6 (0.44) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL28745277 | 0.75 | ORAI1 (0.37) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL262207 | 0.71 | ENPP2 (0.46) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL874879 | 0.71 | TRPV6 (0.42) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL184420 | 0.70 | TRPV6 (0.50) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL5952291 | 0.70 | CA4 (0.32) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| Fluoride SCHEMBL28835775 | 0.70 | ENPP2 (0.44) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL624916 | 0.70 | TRPV6 (0.44) | TRPV6ORAI1ORAI2ORAI3PCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117412967-A | Methionine adenosine transferase 2A inhibitors | 南京正大天晴制药有限公司 | 2024-01-16 | — | — | CN | disclosed |
| WO-2022253242-A1 | METHIONINE ADENOSYLTRANSFERASE 2A INHIBITOR | 南京正大天晴制药有限公司 | 2022-12-08 | — | — | WO | disclosed |
| CN-114127062-A | Thiadiazolyl derivatives as inhibitors of DNA polymerase Theta | 伊迪亚生物科学有限公司 | 2022-03-01 | — | — | CN | disclosed |
| EP-3856178-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | Janssen Pharmaceutica NV (BE) | 2021-08-04 | — | — | EP | disclosed |
| EP-3668873-A1 | IMIDAZO[1,2-A]IMIDAZOL-2-ONE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS PARKINSON'S DISEASE | H. Hoffnabb-La Roche Ag (CH) | 2020-06-24 | — | — | EP | disclosed |
| WO-2020065613-A1 | MONOACYLGLYCEROL LIPASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-02 | — | — | WO | disclosed |
| WO-2019034713-A1 | IMIDAZO[1,2-A]IMIDAZOL-2-ONE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS PARKINSON'S DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2019-02-21 | — | — | WO | disclosed |
| EP-2895478-A1 | TRIAZOLE CARBOXAMIDE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-07-22 | — | — | EP | disclosed |
| WO-2014041106-A1 | TRIAZOLE CARBOXAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-03-20 | — | — | WO | disclosed |