Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.32 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22648279 | 0.84 | SIGMAR1 (0.47) | SIGMAR1DRD4ALDH1A1L3MBTL1ACHE | |
| SCHEMBL22648384 | 0.84 | ALDH1A1 (0.40) | SIGMAR1DRD4ALDH1A1L3MBTL1ACHE | |
| SCHEMBL28425717 | 0.82 | F2 (0.37) | SIGMAR1DRD4ALDH1A1L3MBTL1ACHE | |
| SCHEMBL16513259 | 0.82 | DYRK1A (0.40) | SIGMAR1DRD4ALDH1A1L3MBTL1ACHE | |
| SCHEMBL174612 | 0.81 | F2 (0.41) | SIGMAR1DRD4ALDH1A1L3MBTL1ACHE | |
| SCHEMBL24222179 | 0.81 | SIGMAR1 (0.38) | SIGMAR1DRD4ALDH1A1L3MBTL1ACHE | |
| SCHEMBL30955784 | 0.80 | L3MBTL1 (0.35) | SIGMAR1DRD4ALDH1A1L3MBTL1ACHE | |
| SCHEMBL1558099 | 0.79 | SIRT6 (0.40) | ALDH1A1L3MBTL1ACHEMAP3K7TAB1 | |
| SCHEMBL16196214 | 0.79 | MEN1 (0.42) | SIGMAR1DRD4ALDH1A1L3MBTL1ACHE | |
| SCHEMBL21526529 | 0.79 | FGFR1 (0.41) | SIGMAR1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303861-A1 | PYRIDINE COMPOUNDS | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009153589-A1 | PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | WO | disclosed |