Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.54 |
| ▸ | FDPS | P14324 | 1/20 | 0.54 |
| ▸ | IAPP | P10997 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15580916 | 1.00 | APP (0.54) | APPFDPSIAPPPTGS1GAA | |
| SCHEMBL15580939 | 0.77 | ALDH1A1 (0.53) | FDPSHTTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14926717 | 0.77 | IAPP (0.61) | APPFDPSIAPPPTGS1GAA | |
| SCHEMBL31501092 | 0.76 | ALDH1A1 (0.76) | PTGS1GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5218481 | 0.76 | ALDH1A1 (0.76) | PTGS1GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14930493 | 0.76 | APP (0.71) | APPFDPSIAPPPTGS1GAA | |
| SCHEMBL5218471 | 0.76 | ALDH1A1 (0.76) | PTGS1GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4937166 | 0.76 | FDPS (0.79) | APPFDPSGAAHTTKDM4E | |
| SCHEMBL4937158 | 0.76 | FDPS (0.79) | APPFDPSGAAHTTKDM4E | |
| SCHEMBL10951481 | 0.75 | EPHX2 (0.68) | APPFDPSPTGS1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9434689-B2 | Processes for the preparation of isoindole compounds and isotopologues thereof | CELGENE CORPORATION (US) | 2016-09-06 | — | — | US | disclosed |
| US-20150183739-A1 | PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF | AMGEN INC. | 2015-07-02 | — | — | US | disclosed |
| US-8981117-B2 | Processes for the preparation of isoindole compounds and isotopologues thereof | CELGENE CORPORATION (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140081032-A1 | PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF | CELGENE CORPORATION (US) | 2014-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183739-A1 | PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF | HPD, DHPS, IDH2 | APP 3184/4885FDPS 572/4885IAPP 1274/4885 |
| US-20140081032-A1 | PROCESSES FOR THE PREPARATION OF ISOINDOLE COMPOUNDS AND ISOTOPOLOGUES THEREOF | HPD, DHPS, IDH2 | APP 3184/4885FDPS 572/4885IAPP 1274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.