Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.79 |
| ▸ | APP | P05067 | 3/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.75 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | JUN | P05412 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.63 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4937166 | 1.00 | FDPS (0.79) | FDPSAPPKDM4EALDH1A1HPGD | |
| SCHEMBL16976570 | 0.90 | JUN (0.73) | FDPSAPPKDM4EALDH1A1HPGD | |
| SCHEMBL2026116 | 0.88 | MAOB (0.64) | FDPSAPPKDM4EALDH1A1HPGD | |
| SCHEMBL2026115 | 0.88 | MAOB (0.64) | FDPSAPPKDM4EALDH1A1HPGD | |
| SCHEMBL4937226 | 0.88 | FDPS (0.72) | FDPSAPPKDM4EALDH1A1HPGD | |
| SCHEMBL4937232 | 0.88 | FDPS (0.72) | FDPSAPPKDM4EALDH1A1HPGD | |
| SCHEMBL4937130 | 0.88 | FDPS (0.81) | FDPSAPPKDM4EALDH1A1HPGD | |
| SCHEMBL8692407 | 0.88 | FDPS (0.68) | FDPSAPPKDM4EALDH1A1HPGD | |
| SCHEMBL4937141 | 0.88 | FDPS (0.81) | FDPSAPPKDM4EALDH1A1HPGD | |
| SCHEMBL2743877 | 0.87 | NFKB1 (0.79) | KDM4EALDH1A1HPGDALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117440805-A | Method for treating nonalcoholic steatohepatitis by co-administration of curcumin derivative and TGF-beta receptor inhibitor | 延世大学校原州产学协力团 | 2024-01-23 | — | — | CN | claimed |
| US-20230364069-A1 | METHOD FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS THROUGH CO-ADMINISTRATION OF CURCUMIN DERIVATIVE AND TGF-B RECEPTOR INHIBITOR | UNIVERSITY INDUSTRY FOUNDATION, YONSEI UNIVERSITY WONJU CAMPUS (KR) | 2023-11-16 | — | — | US | claimed |
| EP-4248957-A1 | METHOD FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS THROUGH CO-ADMINISTRATION OF CURCUMIN DERIVATIVE AND TGF-? RECEPTOR INHIBITOR | University Industry Foundation, Yonsei University Wonju Campus (KR) | 2023-09-27 | — | — | EP | claimed |
| WO-2022270760-A1 | METHOD FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS THROUGH CO-ADMINISTRATION OF CURCUMIN DERIVATIVE AND TGF-Β RECEPTOR INHIBITOR | 연세대학교 원주산학협력단 | 2022-12-29 | — | — | WO | claimed |
| US-20250327100-A1 | Strain of Pseudomonas Putida Genetically Modified to Express a Benzalacetone Reductase | BGENE GENETICS (FR) | 2025-10-23 | — | — | US | disclosed |
| CN-117440805-A | Method for treating nonalcoholic steatohepatitis by co-administration of curcumin derivative and TGF-beta receptor inhibitor | 延世大学校原州产学协力团 | 2024-01-23 | — | — | CN | disclosed |
| US-11872236-B2 | Pharmacological agents for treating ocular diseases | CALASIA PHARMACEUTICALS, INC. (US) | 2024-01-16 | — | — | US | disclosed |
| US-20230364069-A1 | METHOD FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS THROUGH CO-ADMINISTRATION OF CURCUMIN DERIVATIVE AND TGF-B RECEPTOR INHIBITOR | UNIVERSITY INDUSTRY FOUNDATION, YONSEI UNIVERSITY WONJU CAMPUS (KR) | 2023-11-16 | — | — | US | disclosed |
| US-20230364069-A1 | METHOD FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS THROUGH CO-ADMINISTRATION OF CURCUMIN DERIVATIVE AND TGF-B RECEPTOR INHIBITOR | UNIVERSITY INDUSTRY FOUNDATION, YONSEI UNIVERSITY WONJU CAMPUS (KR) | 2023-11-16 | — | — | US | disclosed |
| US-20230364069-A1 | METHOD FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS THROUGH CO-ADMINISTRATION OF CURCUMIN DERIVATIVE AND TGF-B RECEPTOR INHIBITOR | UNIVERSITY INDUSTRY FOUNDATION, YONSEI UNIVERSITY WONJU CAMPUS (KR) | 2023-11-16 | — | — | US | disclosed |
| US-20230301984-A1 | CYCLIC COMPOUNDS FOR USE IN TREATING RETINAL DEGENERATION | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-09-28 | — | — | US | disclosed |
| US-20230301984-A1 | CYCLIC COMPOUNDS FOR USE IN TREATING RETINAL DEGENERATION | THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2023-09-28 | — | — | US | disclosed |
| US-5597816-A | Pyrazoloazepino substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents | THE UPJOHN COMPANY (US) | 1997-01-28 | — | — | US | disclosed |
| US-5565468-A | 4,5,6,7-TETRAHYDROPYRAZOLO(1,5-A)PYRID-3-YL, PYRAZOLO(1,5-A)PYRID-3-YL, IMIDAZO(1,5-A)PYRIDIN-1-YL OR IMIDAZO(1,2-A)-PYRID-3-YL OXIME DERIVATIVES | THE UPJOHN COMPANY (US) | 1996-10-15 | — | — | US | disclosed |
| US-5523318-A | Pyrrolidino-substituted oximes useful as anti-atherosclerosis and anti-hypercholesterolemic agents | THE UPJOHN COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0649425-A1 | PYRIDINO-, PYRROLIDINO- AND AZEPINO-SUBSTITUTED OXIMES USEFUL AS ANTI-ATHEROSCLEROSIS AND ANTI-HYPERCHOLESTEROLEMIC AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 1995-04-26 | — | — | EP | disclosed |
| WO-1993025553-A1 | PYRIDINO-, PYRROLIDINO- AND AZEPINO-SUBSTITUTED OXIMES USEFUL AS ANTI-ATHEROSCLEROSIS AND ANTI-HYPERCHOLESTEROLEMIC AGENTS | THE UPJOHN COMPANY (US) | 1993-12-23 | — | — | WO | disclosed |
| EP-0316790-B1 | RHODANINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS AND THEIR USE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1993-08-11 | — | — | EP | disclosed |
| US-4897406-A | CHEMICAL MEDIATOR INHIBITORS INCLUDING LEUKOTRIENES; ANTIALLERGENS; BRONCHODILATOR AND ANTIICHEMIC AGENTS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-01-30 | — | — | US | disclosed |
| EP-0316790-A1 | Rhodanine derivatives, a process for their preparation, pharmaceutical compositions and their use | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1989-05-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11872236-B2 | Pharmacological agents for treating ocular diseases | CRYAA, CRYAB, TTR | FDPS 1640/4885APP 26/4885KDM4E 4852/4885 |
| US-20230301984-A1 | CYCLIC COMPOUNDS FOR USE IN TREATING RETINAL DEGENERATION | ALDH1A2, PDE6D, PDE6C | FDPS 1752/4885APP 252/4885KDM4E 3316/4885 |
| US-20230364069-A1 | METHOD FOR TREATING NON-ALCOHOLIC STEATOHEPATITIS THROUGH CO-ADMINISTRATION OF CURCUMIN DERIVATIVE AND TGF-B RECEPTOR INHIBITOR | TGFBR2, TGFBR1, TGFB1 | FDPS 1803/4885APP 478/4885KDM4E 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.