Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | GNAI3 | P08754 | 9/20 | 0.53 |
| ▸ | GNAI1 | P63096 | 9/20 | 0.53 |
| ▸ | GNAO1 | P09471 | 8/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.47 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14845706 | 0.94 | MEN1 (0.54) | L3MBTL1MEN1KMT2ATDP1GNAI3 | |
| SCHEMBL13097061 | 0.88 | L3MBTL1 (0.60) | L3MBTL1MEN1KMT2ATDP1GNAI3 | |
| SCHEMBL21886617 | 0.88 | L3MBTL1 (0.51) | L3MBTL1MEN1KMT2ATDP1GNAI3 | |
| SCHEMBL11466803 | 0.86 | L3MBTL1 (0.58) | L3MBTL1MEN1KMT2ATDP1GNAI3 | |
| SCHEMBL10290423 | 0.86 | L3MBTL1 (0.58) | L3MBTL1MEN1KMT2ATDP1GNAI3 | |
| SCHEMBL21140125 | 0.86 | GNAI3 (0.53) | L3MBTL1MEN1KMT2ATDP1GNAI3 | |
| SCHEMBL16281802 | 0.86 | L3MBTL1 (0.50) | L3MBTL1MEN1KMT2ATDP1GNAI3 | |
| SCHEMBL24208230 | 0.85 | CHRNB2 (0.62) | L3MBTL1MEN1KMT2ATDP1GNAI3 | |
| SCHEMBL19154137 | 0.85 | CHRNB2 (0.62) | L3MBTL1MEN1KMT2ATDP1GNAI3 | |
| SCHEMBL9908636 | 0.84 | L3MBTL1 (0.47) | L3MBTL1MEN1KMT2ATDP1GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160271105-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2016-09-22 | — | — | US | disclosed |
| US-8952050-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-02-10 | — | — | US | disclosed |
| US-20140080826-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080826-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | L3MBTL1 3601/4885MEN1 4687/4885KMT2A 4313/4885 |
| US-20160271105-A1 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | CFTR, ABCB1, ABCC2 | L3MBTL1 3601/4885MEN1 4687/4885KMT2A 4313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.