SCHEMBL1561072

SCHEMBL1561072

CC(C)C[Al](CC(C)C)Oc1c(-c2ccccc2)cccc1-c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.38
ADRA2B P18089 1/20 0.38
ADRA2C P18825 1/20 0.38
PDCD1 Q15116 1/20 0.36
CD274 Q9NZQ7 1/20 0.36
ADRB2 P07550 1/20 0.33
HTR7 P34969 1/20 0.33
DPP4 P27487 1/20 0.32
MAPT P10636 2/20 0.32
HTT P42858 2/20 0.32
SCN1A P35498 1/20 0.32
SCN2A Q99250 1/20 0.32
SCN3A Q9NY46 1/20 0.32
USP2 O75604 1/20 0.32
LMNA P02545 1/20 0.32
MAPK1 P28482 1/20 0.32
SCN8A Q9UQD0 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
ALDH1A1 P00352 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7735423 0.86 ADRA2A (0.38) ADRA2AADRA2BADRA2CPDCD1CD274
SCHEMBL11116087 0.83 HTR7 (0.42) ADRA2AADRA2BADRA2CADRB2HTR7
SCHEMBL3698066 0.80 PDCD1 (0.39) ADRA2AADRA2BADRA2CPDCD1CD274
SCHEMBL2278908 0.75 PTPN1 (0.37) PDCD1CD274ADRB2MAPK1SCN8A
SCHEMBL7163089 0.74 SCN4A (0.44) ADRA2AADRA2BADRA2CSCN1ASCN2A
SCHEMBL395171 0.74 PDCD1 (0.38) ADRA2AADRA2BADRA2CPDCD1CD274
SCHEMBL1561473 0.74 LMNA (0.41) ADRB2MAPTLMNAALDH1A1
SCHEMBL396393 0.74 PDCD1 (0.38) ADRA2AADRA2BADRA2CPDCD1CD274
SCHEMBL76294 0.73 ALDH1A1 (0.41) ADRA2AADRA2BADRA2CPDCD1CD274
SCHEMBL7741488 0.73 PDCD1 (0.39) ADRA2AADRA2BADRA2CPDCD1CD274

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3009459-B1 OLEFIN POLYMERIZATION PROCESS USING A MODIFIER DOW GLOBAL TECHNOLOGIES LLC (US) 2017-08-02 EP disclosed
EP-3009459-A1 OLEFIN POLYMERIZATION PROCESS USING A MODIFIER Dow Global Technologies LLC (US) 2016-04-20 EP disclosed
EP-1761570-B1 METHOD FOR IDENTIFYING ZIEGLER-NATTA COCATALYSTS DOW GLOBAL TECHNOLOGIES LLC (US) 2014-06-11 EP disclosed
US-8383542-B2 Polymerization modifiers DOW GLOBAL TECHNOLOGIES, LLC (US) 2013-02-26 US disclosed
US-20110184135-A1 POLYMERIZATION MODIFIERS DOW GLOBAL TECHNOLOGIES LLC (US) 2011-07-28 US disclosed
EP-2345677-A2 Technique for selecting polymerization modifiers Dow Global Technologies LLC (US) 2011-07-20 EP disclosed
US-7943546-B2 Polymerization modifiers DOW GLOBAL TECHNOLOGIES LLC (US) 2011-05-17 US disclosed
EP-1763542-B1 TECHNIQUE FOR SELECTING POLYMERIZATION MODIFIERS DOW GLOBAL TECHNOLOGIES INC (US) 2011-04-06 EP disclosed
US-7683003-B2 Method for identifying Ziegler-Natta cocatalysts DOW GLOBAL TECHNOLOGIES, INC. (US) 2010-03-23 US disclosed
US-20090264605-A1 TECHNIQUE FOR SELECTING POLYMERIZATION MODIFIERS CORSS REFERENCE STATEMENT DOW GLOBAL TECHNOLOGIES INC. (US) 2009-10-22 US disclosed
US-7553917-B2 Technique for selecting polymerization modifiers cross reference statement DOW GLOBAL TECHNOLOGIES, INC. (US) 2009-06-30 US disclosed
US-20070276102-A1 Method for Identifying Ziegler-Natta Cocatalysts DOW GLOBAL TECHNOLOGIES INC. 2007-11-29 US disclosed
US-20070219327-A1 Technique for Selecting Polymerization Modifiers Cross Reference Statement DOW GLOBAL TECHNOLOGIES INC. 2007-09-20 US disclosed
EP-1763542-A2 TECHNIQUE FOR SELECTING POLYMERIZATION MODIFIERS CROSS REFERENCE STATEMENT Dow Gloval Technologies Inc. (US) 2007-03-21 EP disclosed
WO-2006007094-A2 TECHNIQUE FOR SELECTING POLYMERIZATION MODIFIERS DOW GLOBAL TECHNOLOGIES INC. (US) 2006-01-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090264605-A1 TECHNIQUE FOR SELECTING POLYMERIZATION MODIFIERS CORSS REFERENCE STATEMENT NOTUM, COASY, WASF2 ADRA2A 4656/4885ADRA2B 4637/4885ADRA2C 4775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.