Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.59 |
| ▸ | PLG | P00747 | 2/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28247458 | 0.83 | PLAU (0.62) | PLAUPLGHDAC8HDAC6HDAC11 | |
| SCHEMBL220038 | 0.82 | PLAU (0.52) | PLAUPLGEPHX2HDAC8HDAC6 | |
| SCHEMBL30067019 | 0.81 | PLAU (0.60) | PLAUPLGHDAC8HDAC6HDAC11 | |
| SCHEMBL221369 | 0.81 | PLAU (0.60) | PLAUPLGHDAC8HDAC6HDAC11 | |
| SCHEMBL27248488 | 0.81 | PLAU (0.60) | PLAUPLGHDAC8HDAC6HDAC11 | |
| SCHEMBL28648394 | 0.80 | HTR6 (0.57) | PLAUPLGEPHX2 | |
| SCHEMBL29424817 | 0.80 | PLAU (0.59) | PLAUPLGHDAC8HDAC6HDAC11 | |
| SCHEMBL22533790 | 0.80 | PLAU (0.59) | PLAUPLGHDAC8HDAC6HDAC11 | |
| SCHEMBL22547752 | 0.80 | PLAU (0.59) | PLAUPLGHDAC8HDAC6HDAC11 | |
| SCHEMBL3891994 | 0.79 | PLAU (0.60) | PLAUPLGEPHX2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708268-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2017-07-18 | — | — | US | disclosed |
| US-9708268-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2017-07-18 | — | — | US | disclosed |
| US-20160130231-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC (US) | 2016-05-12 | — | — | US | disclosed |
| US-20160130231-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC (US) | 2016-05-12 | — | — | US | disclosed |
| US-20150073016-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-03-12 | — | — | US | disclosed |
| US-20150073016-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-03-12 | — | — | US | disclosed |
| WO-2013166013-A1 | ROR MODULATORS AND THEIR USES | GAWECO ANDERSON (US) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160130231-A1 | ROR MODULATORS AND THEIR USES | RORB, RORA, RORC | PLAU 4468/4885PLG 4778/4885EPHX2 963/4885 |
| US-20150073016-A1 | ROR MODULATORS AND THEIR USES | RORB, RORA, RORC | PLAU 4468/4885PLG 4778/4885EPHX2 963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.