Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | HPGD | P15428 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16872898 | 0.89 | ALDH1A1 (0.80) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL19665251 | 0.78 | MPO (0.67) | ALDH1A1PKMMEN1KMT2AHPGD | |
| SCHEMBL2730985 | 0.74 | KMT2A (0.67) | ALDH1A1PKMMEN1KMT2AHPGD | |
| SCHEMBL2731359 | 0.74 | KMT2A (0.70) | ALDH1A1PKMMEN1KMT2AHPGD | |
| SCHEMBL30414309 | 0.74 | KMT2A (0.77) | ALDH1A1PKMMEN1KMT2AHPGD | |
| SCHEMBL6306378 | 0.74 | KMT2A (0.77) | ALDH1A1PKMMEN1KMT2AHPGD | |
| SCHEMBL5652363 | 0.74 | SMN1; SMN2 (0.76) | ALDH1A1KMT2AHPGDSMN1; SMN2KDM4E | |
| SCHEMBL15506189 | 0.71 | GAA (0.65) | ALDH1A1MEN1KMT2AHPGDSMN1; SMN2 | |
| SCHEMBL2731374 | 0.70 | MPO (1.00) | ALDH1A1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL2117984 | 0.70 | ALDH1A1 (0.69) | ALDH1A1PKMMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170348295-A1 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | SIRGA ADVANCED BIOPHARMA INC (US) | 2017-12-07 | — | — | US | disclosed |
| US-20170348295-A1 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | SIRGA ADVANCED BIOPHARMA INC (US) | 2017-12-07 | — | — | US | disclosed |
| US-9775835-B2 | Small molecule inhibitors of viral protein interactions with human t-RNA | SIRGA ADVANCED BIOPHARMA, INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-9775835-B2 | Small molecule inhibitors of viral protein interactions with human t-RNA | SIRGA ADVANCED BIOPHARMA, INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-20150190384-A1 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | SIRGA ADVANCED BIOPHARMA, INC. (US) | 2015-07-09 | — | — | US | disclosed |
| US-20150190384-A1 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | SIRGA ADVANCED BIOPHARMA, INC. (US) | 2015-07-09 | — | — | US | disclosed |
| WO-2014025749-A2 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | SIRGA ADVANCED BIOPHARMA, INC. (US) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348295-A1 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | NSUN3, TARBP1, TRDMT1 | ALDH1A1 4756/4885PKM 4022/4885MEN1 3917/4885 |
| US-20150190384-A1 | SMALL MOLECULE INHIBITORS OF VIRAL PROTEIN INTERACTIONS WITH HUMAN T-RNA | NSUN3, TARBP1, TRDMT1 | ALDH1A1 4753/4885PKM 4051/4885MEN1 3866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.