Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | IDO1 | P14902 | 2/20 | 0.69 |
| ▸ | ALPL | P05186 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | TTK | P33981 | 1/20 | 0.69 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.69 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.58 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.58 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 5/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768403 | 0.83 | ALDH1A1 (1.00) | KDM4EALDH1A1IDO1ALPLGAA | |
| SCHEMBL855531 | 0.83 | ALDH1A1 (1.00) | KDM4EALDH1A1IDO1ALPLGAA | |
| Propionic Acid SCHEMBL4552403 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1IDO1ALPLGAA | |
| SCHEMBL8126956 | 0.82 | MAPK1 (0.72) | KDM4EALDH1A1IDO1ALPLGAA | |
| SCHEMBL17178615 | 0.79 | ALDH1A1 (0.92) | KDM4EALDH1A1IDO1ALPLGAA | |
| SCHEMBL3732433 | 0.78 | MAP2K4 (1.00) | KDM4EALDH1A1IDO1ALPLGAA | |
| SCHEMBL27968462 | 0.76 | ALDH1A1 (0.85) | KDM4EALDH1A1IDO1ALPLGAA | |
| SCHEMBL28741879 | 0.76 | MAP2K4 (0.76) | KDM4EALDH1A1IDO1ALPLGAA | |
| SCHEMBL29640072 | 0.76 | MAP2K4 (0.76) | KDM4EALDH1A1IDO1ALPLGAA | |
| SCHEMBL31760855 | 0.76 | KDM4E (0.65) | KDM4EALDH1A1IDO1ALPLGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738610-B2 | Indazole derivatives and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-08-22 | — | — | US | disclosed |
| US-20150353503-A1 | INDAZOLE DERIVATIVES AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-12-10 | — | — | US | disclosed |
| WO-2014047662-A2 | INDAZOLE DERIVATIVES AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353503-A1 | INDAZOLE DERIVATIVES AND USES THEREOF | CYP11B1, HSP90B1, CYP1B1 | KDM4E 4525/4885ALDH1A1 1340/4885IDO1 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.