Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.41 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3644681 | 0.73 | GPR3 (0.40) | ACHEBCHECHRM2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL29560682 | 0.73 | GPR3 (0.40) | ACHEBCHECHRM2HTR1AADRA2A | |
| SCHEMBL7195132 | 0.72 | ACHE (0.42) | ACHEBCHECHRM2HTR1AADRA2A | |
| Hydrochloric Acid SCHEMBL10181364 | 0.71 | ACHE (0.41) | ACHEBCHECHRM2HTR1AADRA2A | |
| Fluoride Ion SCHEMBL1130436 | 0.69 | GPR3 (0.40) | ACHEBCHECHRM2HTR1AADRA2A | |
| SCHEMBL156230 | 0.69 | ACHE (0.40) | ACHEBCHECHRM2HTR1AADRA2A | |
| SCHEMBL7586684 | 0.69 | ACHE (0.40) | ACHEBCHECHRM2HTR1AADRA2A | |
| SCHEMBL6060938 | 0.68 | HTR2A (0.54) | ACHEBCHE | |
| SCHEMBL1449246 | 0.68 | HTR2A (0.54) | ACHEBCHE | |
| SCHEMBL407781 | 0.68 | HTR2A (0.54) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460834-B1 | Improved acidic activator-supports and catalysts for olefin polymerization | CHEVRON PHILLIPS CHEMICAL CO (US) | 2015-08-12 | — | — | EP | claimed |
| EP-1807456-B1 | ORGANOCHROMIUM/METALLOCENE COMBINATION CATALYST FOR PRODUCING BIMODAL RESINS | CHEVRON PHILLIPS CHEMICAL CO (US) | 2012-07-11 | — | — | EP | claimed |
| EP-2460834-A1 | Improved acidic activator-supports and catalysts for olefin polymerization | Chevron Phillips Chemical Company LP (US) | 2012-06-06 | — | — | EP | claimed |
| US-7622414-B2 | Organometal catalyst compositions | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2009-11-24 | — | — | US | claimed |
| US-20080281063-A9 | Ethylene polymers and copolymers with high optical opacity and methods of making the same | SUKHADIA ASHISH M | 2008-11-13 | — | — | US | claimed |
| JP-2008519092-A | — | — | 2008-06-05 | — | — | JP | claimed |
| WO-2006052232-A9 | ORGANOCHROMIUM/ METALLOCENE COMBINATION CATALYST FOR PRODUCING BIMODAL RESINS | CHEVRON PHILLIPS CHEMICAL CO (US) | 2008-02-07 | — | — | WO | claimed |
| US-20080026934-A1 | ACIDIC ACTIVATOR SUPPORTS AND CATALYSTS FOR OLEFIN POLYMERIZATION | CHEVRON PHILLIPS CHEMICAL COMPANY (US) | 2008-01-31 | — | — | US | claimed |
| EP-1807456-A1 | ORGANOCHROMIUM/ METALLOCENE COMBINATION CATALYST FOR PRODUCING BIMODAL RESINS | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2007-07-18 | — | — | EP | claimed |
| EP-1773897-A2 | IMPROVED ACIDIC ACTIVATOR-SUPPORTS AND CATALYSTS FOR OLEFIN POLYMERIZATION | Chevron Phillips Chemical Company LP (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012321-A2 | IMPROVED ACIDIC ACTIVATOR-SUPPORTS AND CATALYSTS FOR OLEFIN POLYMERIZATION | CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) | 2006-02-02 | — | — | WO | claimed |
| US-6992032-B2 | Organometal catalyst compositions | PHILLIPS PETROLEUM COMPANY (US) | 2006-01-31 | — | — | US | claimed |
| US-20050288178-A1 | Acidic activator-supports and catalysts for olefin polymerization | CHEVRON PHILLIPS CHEMICAL COMPANY | 2005-12-29 | — | — | US | claimed |
| US-20050203261-A1 | Ethylene polymers and copolymers with high optical opacity and methods of making the same | CHEVRON PHILLIPS CHEMICAL COMPANY, L.P. | 2005-09-15 | — | — | US | claimed |
| US-20050137366-A1 | Organometal compound catalyst | MCDANIEL MAX P (US) | 2005-06-23 | — | — | US | claimed |
| US-6858687-B2 | Catalyst compositions that are useful for polymerizing at least one monomer to produce a polymer. This invention also provides catalyst compositions that are useful for polymerizing at least one monomer to produce a polymer, | PHILLIPS PETROLEUM COMPANY (US) | 2005-02-22 | — | — | US | claimed |
| US-6838533-B2 | Organometal catalyst composition | PHILIPS PETROLEUM COMPANY (US) | 2005-01-04 | — | — | US | claimed |
| US-6548441-B1 | Polymerization catalysts comprises an organometal compound, an organoaluminum compound, and a halogenated nickel solid oxide compound; heterogeneous catalysts can lead to form uniform polymer particles that have a high bulk density | PHILLIPS PETROLEUM COMPANY | 2003-04-15 | — | — | US | claimed |
| US-6548442-B1 | Polymerization catalysts comprises an organometal compound, an organoaluminum compound, and a halogenated solid zirconium oxide compound; heterogeneous catalysts can lead to form uniform polymer particles that have a high bulk density | PHILLIPS PETROLEUM COMPANY | 2003-04-15 | — | — | US | claimed |
| US-6355594-B1 | CONTACTING AT LEAST ONE ORGANOMETAL COMPOUND, AT LEAST ONE ORGANOALUMINUM COMPOUND, AND AT LEAST ONE FLUORIDED SILICA-ALUMINA TO PRODUCE POLYMERIZATION CATALYST COMPOSITION | PHILLIPS PETROLEUM COMPANY | 2002-03-12 | — | — | US | claimed |