Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10992504 | 0.92 | CYP2C19 (0.41) | CYP2C19ALDH1A1CYP3A4ALOX15CYP2C9 | |
| SCHEMBL29369499 | 0.87 | CYP2C19 (0.44) | CYP2C19ALDH1A1CYP3A4ALOX15CYP2C9 | |
| SCHEMBL6325 | 0.87 | CYP2C19 (0.44) | CYP2C19ALDH1A1CYP3A4ALOX15CYP2C9 | |
| SCHEMBL1567611 | 0.77 | APLNR (0.38) | CYP2C19ALDH1A1CYP3A4ALOX15CYP2C9 | |
| SCHEMBL18865623 | 0.77 | CYP2C19 (0.46) | CYP2C19ALDH1A1CYP3A4ALOX15CYP2C9 | |
| SCHEMBL29691210 | 0.77 | CYP2C19 (0.46) | CYP2C19ALDH1A1CYP3A4ALOX15CYP2C9 | |
| SCHEMBL12261012 | 0.72 | THRB (0.40) | ALDH1A1IDO1TDO2CA1CA2 | |
| SCHEMBL6205004 | 0.72 | CYP2C19 (0.44) | CYP2C19ALDH1A1CYP3A4ALOX15CYP2C9 | |
| SCHEMBL6205005 | 0.71 | CYP2C19 (0.45) | CYP2C19ALDH1A1CYP3A4ALOX15CYP2C9 | |
| SCHEMBL29428538 | 0.71 | GABRA1 (0.50) | CYP2C19ALDH1A1CYP3A4ALOX15CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4036100-A1 | SPIROKETAL DERIVATIVES AND PROCESS FOR PREPARATION OF SPIROKETAL DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2022-08-03 | — | — | EP | disclosed |
| EP-3170834-B1 | CRYSTALLINE FORMS OF (1S,3'R,4'S,5'S,6'R)-6-[(4-ETHYLPHENYL)METHYL]-3',4',5',6'-TETRAHYDRO-6'-(HYDROXYMETHYL)SPIRO[ISOBENZOFURAN-1(3H) 2'-[2H]PYRAN]-3',4',5'-TRIOL | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2022-02-09 | — | — | EP | disclosed |
| EP-3170834-A1 | CRYSTALLINE FORMS OF (1S,3'R,4'S,5'S,6'R)-6-[(4-ETHYLPHENYL)METHYL]-3',4',5',6'-TETRAHYDRO-6'- (HYDROXYMETHYL)SPIRO[ISOBENZOFURAN-1(3H) 2'-[2H]PYRAN]-3',4',5'-TRIOL | Chugai Seiyaku Kabushiki Kaisha (JP) | 2017-05-24 | — | — | EP | disclosed |
| EP-2308886-B1 | PROCESS FOR THE PRODUCTION OF A SPIROKETAL DERIVATIVE | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2016-12-07 | — | — | EP | disclosed |
| US-9163051-B2 | Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2015-10-20 | — | — | US | disclosed |
| US-20140024817-A1 | CRYSTAL OF SPIROKETAL DERIVATIVES AND PROCESS FOR PREPARATION OF SPIROKETAL DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2014-01-23 | — | — | US | disclosed |
| US-8569520-B2 | Crystal of spiroketal derivatives and process for preparation of spiroketal derivatives | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2013-10-29 | — | — | US | disclosed |
| US-20110306778-A1 | CRYSTAL OF SPIROKETAL DERIVATIVES AND PROCESS FOR PREPARATION OF SPIROKETAL DERIVATIVES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2011-12-15 | — | — | US | disclosed |
| EP-2308886-A1 | CRYSTAL OF SPIROKETAL DERIVATIVE, AND PROCESS FOR PRODUCTION THEREOF | Chugai Seiyaku Kabushiki Kaisha (JP) | 2011-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306778-A1 | CRYSTAL OF SPIROKETAL DERIVATIVES AND PROCESS FOR PREPARATION OF SPIROKETAL DERIVATIVES | KLK6, WNK1, WNK3 | CYP2C19 248/4885ALDH1A1 599/4885CYP3A4 179/4885 |
| US-20140024817-A1 | CRYSTAL OF SPIROKETAL DERIVATIVES AND PROCESS FOR PREPARATION OF SPIROKETAL DERIVATIVES | KLK6, WNK1, WNK3 | CYP2C19 248/4885ALDH1A1 599/4885CYP3A4 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.