Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476433 | 0.81 | MAPT (0.45) | GAASMN1; SMN2MAPTALDH1A1TDP1 | |
| SCHEMBL9547196 | 0.81 | CA1 (0.41) | GAASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL8930990 | 0.81 | TRPV1 (0.47) | GAASMN1; SMN2MAPTALDH1A1CA1 | |
| SCHEMBL490629 | 0.80 | CA12 (0.58) | MAPTL3MBTL1MEN1KMT2ACA1 | |
| SCHEMBL2231647 | 0.80 | GAA (0.58) | GAASMN1; SMN2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL20984621 | 0.77 | GAA (0.62) | GAASMN1; SMN2MAPTALDH1A1TDP1 | |
| SCHEMBL9461879 | 0.77 | GAA (0.62) | GAASMN1; SMN2MAPTALDH1A1TDP1 | |
| SCHEMBL8020298 | 0.77 | PTGS2 (0.55) | GAASMN1; SMN2MAPTALDH1A1TDP1 | |
| Hydrogen Sulfide SCHEMBL8030072 | 0.75 | PTGS2 (0.54) | GAASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL11685105 | 0.75 | ALDH1A1 (0.58) | GAASMN1; SMN2MAPTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104812748-B | Pyrazoline GPR40 conditioning agents | 百时美施贵宝公司 | 2017-10-24 | — | — | CN | disclosed |
| US-9656963-B2 | Dihydropyrazole GPR40 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-05-23 | — | — | US | disclosed |
| US-9604964-B2 | Dihydropyrazole GPR40 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-28 | — | — | US | disclosed |
| EP-2925749-B1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2016-10-26 | — | — | EP | disclosed |
| EP-2925726-B1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2016-10-26 | — | — | EP | disclosed |
| US-20160297797-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2016-10-13 | — | — | US | disclosed |
| US-20160280659-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2016-09-29 | — | — | US | disclosed |
| EP-2920165-B1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2016-09-28 | — | — | EP | disclosed |
| EP-2925726-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | Bristol-Myers Squibb Company (US) | 2015-10-07 | — | — | EP | disclosed |
| EP-2925749-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | Bristol-Myers Squibb Company (US) | 2015-10-07 | — | — | EP | disclosed |
| EP-2920165-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | Bristol-Myers Squibb Company (US) | 2015-09-23 | — | — | EP | disclosed |
| US-9133163-B2 | Dihydropyrazole GPR40 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-09-15 | — | — | US | disclosed |
| CN-104903296-A | Dihydropyrazole GPR40 modulators | BRISTOL MYERS SQUIBB CO | 2015-09-09 | — | — | CN | disclosed |
| CN-104812748-A | Dihydropyrazole GPR40 modulators | BRISTOL MYERS SQUIBB CO | 2015-07-29 | — | — | CN | disclosed |
| WO-2014078610-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-22 | — | — | WO | disclosed |
| WO-2014078608-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-22 | — | — | WO | disclosed |
| WO-2014078611-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-22 | — | — | WO | disclosed |
| US-20140142139-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280659-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | GPR55, GPR35, GPR65 | GAA 4063/4885SMN1; SMN2 4750/4885MAPT 3588/4885 |
| US-20160297797-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | GPR55, GPR65, GPR35 | GAA 3939/4885SMN1; SMN2 4736/4885MAPT 3496/4885 |
| US-20140142139-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | GPR55, GPR35, GPR65 | GAA 4063/4885SMN1; SMN2 4750/4885MAPT 3588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.