Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN4A | P35499 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15713895 | 0.86 | SCN4A (0.44) | SCN4ACASP1IKBKBRAD51MAPT | |
| SCHEMBL8471355 | 0.77 | PHGDH (0.49) | SCN4ACASP1RAD51MAPTTHRB | |
| Hydrochloric Acid SCHEMBL9124640 | 0.74 | SCN4A (0.43) | SCN4ACASP1IKBKBRAD51MAPT | |
| SCHEMBL15610305 | 0.71 | MAPT (0.45) | SCN4AIKBKBRAD51MAPTTHRB | |
| SCHEMBL3393979 | 0.70 | PDE4B (0.50) | RAD51MAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL25433738 | 0.70 | MAPT (0.50) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL29413798 | 0.69 | RAD51 (0.44) | SCN4ARAD51MAPTTHRBNPY5R | |
| SCHEMBL12003368 | 0.69 | BCHE (0.47) | MAPTTHRBALDH1A1MEN1KMT2A | |
| SCHEMBL3396698 | 0.69 | GABRA1 (0.44) | SCN4ACASP1RAD51ALDH1A1SMN1; SMN2 | |
| SCHEMBL14132597 | 0.68 | ADORA2A (0.54) | MAPTALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695127-B2 | Compounds for treating HIV and methods for using the compounds | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-07-04 | — | — | US | disclosed |
| US-9695127-B2 | Compounds for treating HIV and methods for using the compounds | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150291534-A1 | COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-15 | — | — | US | disclosed |
| US-20150291534-A1 | COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-15 | — | — | US | disclosed |
| WO-2014074628-A1 | COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291534-A1 | COMPOUNDS FOR TREATING HIV AND METHODS FOR USING THE COMPOUNDS | PNMT, NEFM, DUT | SCN4A 4343/4885CASP1 3007/4885IKBKB 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.