Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 4/20 | 0.35 |
| ▸ | CTSK | P43235 | 4/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL584547 | 0.85 | SCN9A (0.49) | SCN9ACYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL585379 | 0.80 | SCN9A (0.47) | SCN9ACYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL17071630 | 0.79 | KLK5 (0.43) | SCN9ACYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL12035787 | 0.76 | MTNR1A (0.46) | SCN9ATACR1CTSSCTSKEPHX2 | |
| SCHEMBL13352198 | 0.76 | MTNR1A (0.46) | SCN9ATACR1MAPTSMN1; SMN2CTSS | |
| SCHEMBL17061439 | 0.76 | MTNR1A (0.46) | SCN9ATACR1ALDH1A1MAPTCTSS | |
| SCHEMBL15962599 | 0.75 | SCN9A (0.51) | SCN9ACYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL4651817 | 0.74 | KLK5 (0.41) | SCN9ACYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL17118205 | 0.74 | MTNR1A (0.51) | SCN9ACYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL29361110 | 0.73 | SCN9A (0.50) | SCN9ACYP1A2CYP2C9CYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307337-B1 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | UNIV CALIFORNIA (US) | 2016-01-13 | — | — | EP | disclosed |
| US-8674101-B2 | Nucleophilic fluorination of aromatic compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-03-18 | — | — | US | disclosed |
| US-20110178302-A1 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-07-21 | — | — | US | disclosed |
| EP-2307337-A2 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | The Regents Of The University Of California (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010008522-A2 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178302-A1 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | SLC18A2, AFF4, SLC6A19 | SCN9A 1657/4885CYP1A2 1813/4885CYP2C9 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.