Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 9/20 | 0.44 |
| ▸ | CTSK | P43235 | 8/20 | 0.44 |
| ▸ | CTSB | P07858 | 4/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739186 | 0.88 | ACE (0.52) | CTSSCTSKCTSBACEPPARG | |
| SCHEMBL4801481 | 0.88 | ACE (0.52) | CTSSCTSKCTSBACEPPARG | |
| SCHEMBL4117611 | 0.87 | REN (0.46) | CTSSCTSKCTSBACEPPARG | |
| SCHEMBL4117607 | 0.87 | REN (0.46) | CTSSCTSKCTSBACEPPARG | |
| SCHEMBL17709322 | 0.86 | SCN9A (0.46) | SCN9ACYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL26017394 | 0.85 | DRD1 (0.49) | ALDH1A1MAPTTACR1 | |
| SCHEMBL1214530 | 0.84 | DRD1 (0.42) | SCN9ATACR1CTSSCTSKCTSB | |
| SCHEMBL15962596 | 0.83 | SCN9A (0.51) | SCN9ACYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL5312623 | 0.82 | CYP1A2 (0.49) | SCN9ACYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL1218073 | 0.82 | DRD1 (0.41) | SCN9AALDH1A1MAPTTACR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417119-B1 | NO-CARRIER-ADDED NUCLEOPHILIC ÝF-18¨FLUORINATION OF AROMATIC COMPOUNDS | UNIV CALIFORNIA (US) | 2016-12-21 | — | — | EP | disclosed |
| EP-2307337-B1 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | UNIV CALIFORNIA (US) | 2016-01-13 | — | — | EP | disclosed |
| US-8742139-B2 | No-carrier-added nucleophilic [F-18] fluorination of aromatic compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-06-03 | — | — | US | disclosed |
| US-8674101-B2 | Nucleophilic fluorination of aromatic compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-03-18 | — | — | US | disclosed |
| US-20120123120-A1 | No-Carrier-Added Nucleophilic [F-18] Fluorination of Aromatic Compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-05-17 | — | — | US | disclosed |
| EP-2417119-A2 | NO-CARRIER-ADDED NUCLEOPHILIC ÝF-18¨FLUORINATION OF AROMATIC COMPOUNDS | The Regents of The University of California (US) | 2012-02-15 | — | — | EP | disclosed |
| US-20110178302-A1 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-07-21 | — | — | US | disclosed |
| EP-2307337-A2 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | The Regents Of The University Of California (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010117435-A2 | NO-CARRIER-ADDED NUCLEOPHILIC [F-18] FLUORINATION OF AROMATIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010008522-A2 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120123120-A1 | No-Carrier-Added Nucleophilic [F-18] Fluorination of Aromatic Compounds | SLC18A1, SLC18A2, SLC6A2 | SCN9A 1056/4885CYP1A2 765/4885CYP2C9 522/4885 |
| US-20110178302-A1 | NUCLEOPHILIC FLUORINATION OF AROMATIC COMPOUNDS | SLC18A2, AFF4, SLC6A19 | SCN9A 1657/4885CYP1A2 1813/4885CYP2C9 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.