Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 7/20 | 0.46 |
| ▸ | NOS2 | P35228 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 3/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | F12 | P00748 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29435659 | 1.00 | NOS3 (0.46) | NOS3NOS2TSHRGLAPOLB | |
| SCHEMBL30356572 | 0.80 | NOS3 (0.41) | NOS3NOS2TSHRGLAPOLB | |
| SCHEMBL29460079 | 0.78 | PIK3CD (0.45) | NOS3NOS2TSHRGLAPOLB | |
| SCHEMBL31097846 | 0.78 | NOS2 (0.39) | NOS3NOS2TSHRGLAPOLB | |
| SCHEMBL30401019 | 0.78 | NOS3 (0.39) | NOS3NOS2TSHRGLAPOLB | |
| SCHEMBL31358429 | 0.78 | NOS3 (0.39) | NOS3NOS2TSHRGLAPOLB | |
| SCHEMBL31312548 | 0.78 | NOS2 (0.54) | NOS3NOS2TSHRGLAPOLB | |
| SCHEMBL11710154 | 0.78 | NOS3 (0.39) | NOS3NOS2TSHRGLAPOLB | |
| SCHEMBL21543486 | 0.78 | PIK3CD (0.45) | NOS3NOS2TSHRGLAPOLB | |
| SCHEMBL20088854 | 0.78 | NOS2 (0.39) | NOS3NOS2TSHRGLAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2436672-B1 | ANTI-SHOCK AGENT COMPRISING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVE | ISHIHARA SANGYO KAISHA (JP) | 2017-04-12 | — | — | EP | claimed |
| US-8604212-B2 | Anti-shock agent comprising diaminotrifluoromethylpyridine derivative | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2013-12-10 | — | — | US | claimed |
| US-20120059039-A1 | ANTI-SHOCK AGENT COMPRISING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVE | ISHIHARA SANGYO KAISHA LTD (JP) | 2012-03-08 | — | — | US | claimed |
| EP-1576093-A4 | 3-DEOXYGLUCOSONE AND SKIN | DYNAMIS THERAPEUTICS INC (US) | 2009-07-08 | — | — | EP | claimed |
| EP-1252890-B1 | REMEDIES OR PREVENTIVES FOR DIGESTIVE DISEASES CONTAINING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES | ISHIHARA SANGYO KAISHA (JP) | 2008-07-02 | — | — | EP | claimed |
| US-20070065443-A1 | Fructoseamine 3 kinase and the formation of collagen and elastin | DYNAMIS THERAPEUTICS, INC. | 2007-03-22 | — | — | US | claimed |
| EP-1753861-A2 | FRUCTOSEAMINE 3 KINASE AND THE FORMATION OF COLLAGEN AND ELASTIN | Dynamis Therapeutics, Inc. (US) | 2007-02-21 | — | — | EP | claimed |
| EP-1252889-B1 | REMEDIES OR PREVENTIVES FOR PULMONARY INSUFFICIENCY CONTAINING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES | ISHIHARA SANGYO KAISHA (JP) | 2006-08-09 | — | — | EP | claimed |
| EP-1252891-B1 | Use of DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES FOR the prevention and treatment of LIVER DISEASES | ISHIHARA SANGYO KAISHA (JP) | 2005-10-05 | — | — | EP | claimed |
| EP-1576093-A2 | 3-DEOXYGLUCOSONE AND SKIN | Dynamis Therapeutics, Inc. (US) | 2005-09-21 | — | — | EP | claimed |
| EP-0465913-B1 | Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them | ISHIHARA SANGYO KAISHA (JP) | 1997-09-10 | — | — | EP | claimed |
| US-5492908-A | ANTIARTHRITIC | ISHIHARA SANGYO KAISHA LTD. (JP) | 1996-02-20 | — | — | US | claimed |
| US-5348967-A | Diaminotrifluoromethylpyridine derivatives, process for their production and phospholipase A2 inhibitor containing them | ISHIHARA SANGYO KAISHA LTD. (JP) | 1994-09-20 | — | — | US | claimed |
| US-5260320-A | Diaminotrifluoromethylpyridine compounds and phospholipase A2 inhibitor containing them | ISHIHARA SANGYO KAISHA LTD. (JP) | 1993-11-09 | — | — | US | claimed |
| US-5229403-A | Enzyme inhibitors, antiinflammatory | ISHIHARA SANGYO KAISHA LTD. (JP) | 1993-07-20 | — | — | US | claimed |
| EP-0465913-A2 | Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1992-01-15 | — | — | EP | claimed |
| US-5032279-A | Placing a mixture of solutions on one side of filter and one preferentially passes through; permselectivity | OCCIDENTAL CHEMICAL CORPORATION (US) | 1991-07-16 | — | — | US | claimed |
| EP-0428095-A2 | Solvent resistant polyimidesiloxane | OCCIDENTAL CHEMICAL CORPORATION (US) | 1991-05-22 | — | — | EP | claimed |
| EP-0418883-A1 | Separation of fluids using polyimidesiloxane membrane | OCCIDENTAL CHEMICAL CORPORATION (US) | 1991-03-27 | — | — | EP | claimed |
| US-4997908-A | Polyimide-siloxane copolymer | OCCIDENTAL CHEMICAL CORPORATION (US) | 1991-03-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070065443-A1 | Fructoseamine 3 kinase and the formation of collagen and elastin | FN3K, PDXK, COLGALT1 | NOS3 1525/4885NOS2 2809/4885TSHR 4155/4885 |
| US-20120059039-A1 | ANTI-SHOCK AGENT COMPRISING DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVE | LITAF, HSF1, MYD88 | NOS3 457/4885NOS2 408/4885TSHR 4327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.