Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PDE2A | O00408 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2750560 | 0.82 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2APDE2ASMN1; SMN2 | |
| SCHEMBL30361145 | 0.82 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2APDE2ASMN1; SMN2 | |
| SCHEMBL2361091 | 0.81 | OGA (0.42) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL17206376 | 0.70 | SMN1; SMN2 (0.56) | ALDH1A1MEN1KMT2APDE2ASMN1; SMN2 | |
| SCHEMBL28848742 | 0.67 | SMN1; SMN2 (0.67) | ALDH1A1MEN1KMT2APDE2ASMN1; SMN2 | |
| SCHEMBL5063006 | 0.65 | L3MBTL1 (0.44) | ALDH1A1MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL5057013 | 0.65 | KMT2A (0.32) | ALDH1A1MEN1KMT2APDE2AL3MBTL1 | |
| SCHEMBL2334323 | 0.65 | LMNA (0.38) | ALDH1A1LMNAL3MBTL1GAA | |
| SCHEMBL30361116 | 0.65 | LMNA (0.38) | ALDH1A1LMNAL3MBTL1GAA | |
| SCHEMBL17205885 | 0.64 | PDE2A (1.00) | PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968237-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2919788-A1 | METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA | The Johns Hopkins University (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014144663-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014078568-A1 | METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-05-22 | — | — | WO | disclosed |