Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OGA | O60502 | 15/20 | 0.42 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15720108 | 0.81 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL1665759 | 0.81 | ALDH1A1 (0.35) | OGAALDH1A1PSEN1PSEN2APH1B | |
| SCHEMBL25625991 | 0.75 | ALDH1A1 (0.56) | OGAACKR3SMN1; SMN2HTTOPRK1 | |
| SCHEMBL21370279 | 0.74 | OGA (0.44) | OGAACKR3SMN1; SMN2HTTOPRK1 | |
| SCHEMBL21369566 | 0.74 | OGA (0.44) | OGAACKR3SMN1; SMN2HTTOPRK1 | |
| SCHEMBL21369427 | 0.73 | OGA (0.49) | OGAACKR3SMN1; SMN2HTTOPRK1 | |
| SCHEMBL21369604 | 0.73 | OGA (0.41) | OGAACKR3SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL24862748 | 0.73 | OGA (0.48) | OGAACKR3SMN1; SMN2HTTOPRK1 | |
| SCHEMBL21370130 | 0.72 | ALDH1A1 (0.67) | OGASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL21370128 | 0.72 | OGA (0.40) | OGAACKR3SMN1; SMN2HTTOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533645-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100373-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |