Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 6/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | BCR | P11274 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574020 | 0.83 | L3MBTL1 (0.47) | ROCK1AHRL3MBTL1 | |
| SCHEMBL1573919 | 0.77 | HRH4 (0.47) | MAP2K4MAPK1MAPK6ABL1BCR | |
| SCHEMBL1573862 | 0.76 | ALDH1A1 (0.44) | MAP2K4RBP4MAPK1MAPK6ABL1 | |
| SCHEMBL1574085 | 0.75 | ALOX15 (0.54) | MAP2K4RBP4MAPK1 | |
| SCHEMBL1573781 | 0.74 | MAP2K4 (0.41) | ROCK1MAP2K4AHRRBP4MAPK1 | |
| SCHEMBL1573854 | 0.74 | RBP4 (0.45) | MAP2K4RBP4MAPK1MAPK6ABL1 | |
| SCHEMBL1574198 | 0.74 | TP53 (0.47) | MAP2K4MAPK1MAPK6ABL1BCR | |
| SCHEMBL1573920 | 0.74 | MAP2K4 (0.41) | ROCK1MAP2K4AHRRBP4MAPK1 | |
| SCHEMBL1573971 | 0.73 | MAP2K4 (0.42) | MAP2K4RBP4MAPK1MAPK6ABL1 | |
| SCHEMBL1574048 | 0.73 | GRM4 (0.41) | MAP2K4RBP4MAPK1MAPK6ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |