SCHEMBL15740342

SCHEMBL15740342

NC(N)=NC(=S)Nc1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 1.00
RAB9A P51151 4/20 1.00
ALDH1A1 P00352 4/20 1.00
MAPT P10636 3/20 0.53
KDM4E B2RXH2 1/20 0.53
SMN1; SMN2 Q16637 2/20 0.51
GAA P10253 5/20 0.49
MAPK1 P28482 3/20 0.46
LMNA P02545 2/20 0.46
CYP1A2 P05177 2/20 0.46
ADRA2A P08913 2/20 0.46
CYP2D6 P10635 2/20 0.46
SLC6A2 P23975 2/20 0.46
SLC6A4 P31645 2/20 0.46
SLC6A3 Q01959 2/20 0.46
KCNH2 Q12809 2/20 0.46
GFER P55789 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
DRD1 P21728 1/20 0.46
NOX1 Q9Y5S8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4551270 0.80 GAA (0.70) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL9725073 0.79 ALDH1A1 (0.66) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL4401662 0.77 RAB9A (0.62) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL11501546 0.77 ALDH1A1 (0.62) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL526059 0.77 MAPT (0.63) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL5035164 0.76 ALDH1A1 (0.63) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL5035161 0.76 ALDH1A1 (0.63) NPC1RAB9AALDH1A1MAPTKDM4E
Thiourea SCHEMBL1991944 0.75 MAPT (0.73) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL27517394 0.75 MAPT (0.61) NPC1RAB9AALDH1A1MAPTKDM4E
SCHEMBL5445907 0.72 MAPT (0.75) NPC1RAB9AALDH1A1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014081856-A2 LIGANDS THAT TARGET HCV-E2 BINDING SITES ON CD81 AND THERAPEUTIC METHODS USING THEM AZZAZY HASSAN (EG) 2014-05-30 WO disclosed