Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035164 | 1.00 | ALDH1A1 (0.63) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL15740342 | 0.76 | NPC1 (1.00) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL9725073 | 0.74 | ALDH1A1 (0.66) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL5028936 | 0.72 | SMN1; SMN2 (0.58) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL5030205 | 0.72 | SMN1; SMN2 (0.58) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL526059 | 0.71 | MAPT (0.63) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL5445907 | 0.71 | MAPT (0.75) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL8956455 | 0.71 | MAPT (0.75) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL5032606 | 0.70 | MAPT (0.55) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT | |
| SCHEMBL5032613 | 0.70 | MAPT (0.55) | ALDH1A1RAB9ASMN1; SMN2NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371751-B2 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2008-05-13 | — | — | US | disclosed |
| EP-1694673-B1 | THIAZOLE DERIVATES | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | EP | disclosed |
| US-20050153962-A1 | Thiazole derivatives | HOFFMANN-LA ROCHE INC. | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153962-A1 | Thiazole derivatives | CNR1, CNR2, GPR119 | ALDH1A1 473/4885RAB9A 1847/4885SMN1; SMN2 3460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.