SCHEMBL15745658

SCHEMBL15745658

CC(O)(c1cc(Cc2cc(Cl)c(N)c(C(C)(O)C(F)(F)F)c2)cc(Cl)c1N)C(F)(F)F

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 7/20 0.39
ADRB1 P08588 3/20 0.39
AR P10275 1/20 0.36
HSD11B1 P28845 5/20 0.35
CYP3A4 P08684 2/20 0.34
LMNA P02545 2/20 0.33
HTR1A P08908 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
ADRA1A P35348 1/20 0.33
OPRK1 P41145 1/20 0.33
SLC6A3 Q01959 1/20 0.33
TSHR P16473 1/20 0.33
KDM4E B2RXH2 1/20 0.32
IDO1 P14902 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15745662 0.83 AR (0.32) ADRB2ARLMNAKDM4E
SCHEMBL15764640 0.83 MEN1 (0.44) ADRB2ADRB1ARCYP3A4LMNA
SCHEMBL15745652 0.82 AR (0.34) AR
SCHEMBL15745659 0.81 AR (0.30) AR
SCHEMBL15745661 0.81 ADRB2 (0.40) ADRB2AR
SCHEMBL15745646 0.79 HSPA5 (0.38) ARHSD11B1
SCHEMBL15745653 0.77 AR (0.34) AR
SCHEMBL19465254 0.76 MEN1 (0.38) LMNATSHRKDM4E
SCHEMBL15745654 0.75 TYR (0.33)
SCHEMBL10002079 0.73 SMN1; SMN2 (0.45) ARHSD11B1CYP3A4TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9793483-B2 Hexafluoroisopropanol group-containing diamine, polyimide and polyamide using same, cyclized product thereof, and method for producing same CENTRAL GLASS COMPANY, LIMITED (JP) 2017-10-17 US disclosed
US-20140148571-A1 Hexafluoroisopropanol Group-Containing Diamine, Polyimide And Polyamide Using Same, Cyclized Product Thereof, And Method For Producing Same CENTRAL GLASS COMPANY, LIMITED (JP) 2014-05-29 US disclosed