Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775174 | 0.83 | PPARG (0.51) | PPARGBCHEMAPK1KDM4EMAPT | |
| SCHEMBL15775209 | 0.83 | PPARG (0.47) | PPARGBCHEMAPK1KDM4EMAPT | |
| SCHEMBL15775291 | 0.79 | PPARG (0.52) | PPARGBCHEMAPK1KDM4EMAPT | |
| SCHEMBL8428563 | 0.73 | BCHE (0.65) | PPARGBCHEMAPK1KDM4EMAPT | |
| SCHEMBL8428963 | 0.73 | BCHE (0.65) | BCHEKDM4EMAPTPOLBGAA | |
| SCHEMBL8428762 | 0.73 | MAPT (0.63) | PPARGBCHEMAPK1KDM4EMAPT | |
| SCHEMBL3240026 | 0.72 | MAPT (0.58) | PPARGBCHEMAPK1KDM4EMAPT | |
| SCHEMBL15775131 | 0.71 | PPARG (0.71) | PPARGBCHEMAPK1KDM4EMAPT | |
| SCHEMBL8426652 | 0.71 | BCHE (0.67) | PPARGBCHEKDM4EMAPTGAA | |
| SCHEMBL15775918 | 0.70 | AR (0.46) | PPARGMAPK1KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014086478-A1 | INHIBITORS OF MALT1 PROTEASE | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2014-06-12 | — | — | WO | claimed |
| WO-2014086478-A1 | INHIBITORS OF MALT1 PROTEASE | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2014-06-12 | — | — | WO | disclosed |