Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | Q9HBH1 | 1/20 | 0.44 | |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8428563 | 0.86 | BCHE (0.65) | PPARGMAPK1KDM4EMAPTGAA | |
| SCHEMBL15775176 | 0.85 | PPARG (0.70) | PPARGMAPK1KDM4EMAPTGAA | |
| SCHEMBL15775210 | 0.82 | PPARG (0.69) | PPARGMAPK1KDM4EMAPTGAA | |
| SCHEMBL15775293 | 0.80 | MAPK1 (0.82) | PPARGMAPK1KDM4EMAPTGAA | |
| SCHEMBL8426652 | 0.78 | BCHE (0.67) | PPARGKDM4EMAPTGAAALDH1A1 | |
| SCHEMBL8428762 | 0.77 | MAPT (0.63) | PPARGMAPK1KDM4EMAPTGAA | |
| SCHEMBL8430522 | 0.76 | MAPT (0.63) | MAPTGAAALDH1A1MEN1LMNA | |
| SCHEMBL3240026 | 0.74 | MAPT (0.58) | PPARGMAPK1KDM4EMAPTGAA | |
| SCHEMBL15775129 | 0.71 | PPARG (0.47) | PPARGMAPK1KDM4EMAPTGAA | |
| SCHEMBL15775919 | 0.71 | KDM4E (0.64) | PPARGMAPK1KDM4EMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014086478-A1 | INHIBITORS OF MALT1 PROTEASE | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2014-06-12 | — | — | WO | claimed |
| WO-2014086478-A1 | INHIBITORS OF MALT1 PROTEASE | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2014-06-12 | — | — | WO | disclosed |
| WO-2014086478-A1 | INHIBITORS OF MALT1 PROTEASE | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2014-06-12 | — | — | WO | disclosed |