Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EED | O75530 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775552 | 0.88 | CYP11B2 (0.42) | CYP11B2NPC1RAB9AMAPTEED | |
| SCHEMBL15776946 | 0.81 | TIPARP (0.43) | CA12CA2CA9CYP2C9TIPARP | |
| SCHEMBL5316899 | 0.77 | POLB (0.40) | NPC1MAOBTIPARPALDH1A1KDM4E | |
| SCHEMBL24326382 | 0.75 | ALDH1A1 (0.52) | RAB9AMAPTCA12CA1CA2 | |
| SCHEMBL5821415 | 0.73 | MITF (0.40) | CYP11B2RAB9AMAPTMAOAMAOB | |
| SCHEMBL15777255 | 0.73 | CA12 (0.42) | CYP11B2MAPTCA12CA1CA2 | |
| SCHEMBL15775371 | 0.70 | TIPARP (0.43) | CA12CA2CA9PDE3BPDE3A | |
| SCHEMBL10311113 | 0.69 | EED (0.41) | CYP11B2NPC1RAB9AMAPTEED | |
| SCHEMBL6591115 | 0.68 | EED (0.75) | NPC1RAB9AMAPTEEDALDH1A1 | |
| SCHEMBL17876310 | 0.67 | CYP11B2 (0.48) | CYP11B2NPC1RAB9ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |