Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.34 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775785 | 0.88 | TNKS (0.41) | PARP1MAPTTRPV1TP53TNKS | |
| SCHEMBL15775398 | 0.86 | RAB9A (0.40) | PARP1ACHEALDH1A1MAPTPARP10 | |
| SCHEMBL15775397 | 0.84 | ACHE (0.40) | PARP1ACHEALDH1A1MAPTTDP1 | |
| SCHEMBL15775414 | 0.83 | SMN1; SMN2 (0.38) | PARP1ACHEALDH1A1MAPTTDP1 | |
| SCHEMBL15776267 | 0.83 | NOTUM (0.39) | PARP1ACHEALDH1A1MAPTPARP10 | |
| SCHEMBL15775238 | 0.82 | PARP10 (0.39) | PARP1ACHEPARP10PARP11 | |
| SCHEMBL15775739 | 0.81 | TNKS (0.40) | PARP1ALDH1A1MAPTTDP1L3MBTL1 | |
| SCHEMBL15775566 | 0.79 | KCNH2 (0.35) | ACHEALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL15775471 | 0.76 | PDCD1 (0.35) | PARP1ACHEMAPTPARP10PARP11 | |
| SCHEMBL15775815 | 0.76 | GRM2 (0.40) | MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |