Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775398 | 0.89 | RAB9A (0.40) | ACHERAB9ASMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL15775238 | 0.88 | PARP10 (0.39) | ACHEPARP1PARP10PARP11GAA | |
| SCHEMBL15775566 | 0.88 | KCNH2 (0.35) | ACHERAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL15775414 | 0.87 | SMN1; SMN2 (0.38) | ACHERAB9ASMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL15776267 | 0.87 | NOTUM (0.39) | ACHERAB9ASMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL15775815 | 0.84 | GRM2 (0.40) | KDM4EMAPTKMT2AGAAMAOB | |
| SCHEMBL15775159 | 0.84 | PARP1 (0.36) | ACHERAB9ASMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL15775739 | 0.84 | TNKS (0.40) | RAB9ASMN1; SMN2ALDH1A1PARP1NPC1 | |
| SCHEMBL15775785 | 0.83 | TNKS (0.41) | PARP1MAPTMAOAMAOB | |
| SCHEMBL15775467 | 0.82 | ALDH1A1 (0.36) | RAB9ASMN1; SMN2ALDH1A1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | claimed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |