Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775398 | 0.88 | RAB9A (0.40) | SMN1; SMN2NPC1RAB9ATSHRTNKS | |
| SCHEMBL15775397 | 0.87 | ACHE (0.40) | SMN1; SMN2NPC1RAB9ATSHRACHE | |
| SCHEMBL15776267 | 0.86 | NOTUM (0.39) | SMN1; SMN2NPC1RAB9ATSHRTNKS | |
| SCHEMBL15775238 | 0.84 | PARP10 (0.39) | ACHEGAAPARP1PARP10PARP11 | |
| SCHEMBL15775739 | 0.83 | TNKS (0.40) | SMN1; SMN2NPC1RAB9ATSHRTNKS | |
| SCHEMBL15775159 | 0.83 | PARP1 (0.36) | SMN1; SMN2NPC1RAB9ATNKSTNKS2 | |
| SCHEMBL15775729 | 0.83 | CHRM5 (0.35) | SMN1; SMN2TSHRGAAMAOBPTPRC | |
| SCHEMBL15775785 | 0.82 | TNKS (0.41) | TNKSTNKS2PARP2PARP1MAOB | |
| SCHEMBL15775566 | 0.81 | KCNH2 (0.35) | SMN1; SMN2NPC1RAB9AACHEKMT2A | |
| SCHEMBL15775471 | 0.78 | PDCD1 (0.35) | SMN1; SMN2ACHEGAAPARP1PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | claimed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |