Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KLK3 | P07288 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5067323 | 0.85 | TDP1 (0.49) | MAPTTDP1ALDH1A1GAALMNA | |
| SCHEMBL15775820 | 0.74 | PARP1 (0.64) | MAPTTDP1ALDH1A1GAALMNA | |
| SCHEMBL849667 | 0.74 | MAPT (0.97) | MAPTTDP1ALDH1A1LMNANPC1 | |
| SCHEMBL28045491 | 0.72 | MAPT (1.00) | MAPTTDP1ALDH1A1LMNAELANE | |
| SCHEMBL7078053 | 0.70 | ELANE (0.58) | MAPTALDH1A1GAAELANEALOX15 | |
| Dihydroartemidin SCHEMBL28045625 | 0.69 | MAPT (0.88) | MAPTTDP1ALDH1A1LMNAELANE | |
| SCHEMBL15775344 | 0.69 | MAOA (0.57) | MAPTTDP1ALDH1A1GAALMNA | |
| SCHEMBL15775643 | 0.68 | MAOB (0.46) | MAPTTDP1ALDH1A1GAAMEN1 | |
| Hexane SCHEMBL27460259 | 0.68 | HSD17B10 (0.56) | MAPTTDP1ALDH1A1GAALMNA | |
| SCHEMBL2244893 | 0.68 | ALDH1A1 (0.56) | MAPTALDH1A1GAALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |