Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KLK3 | P07288 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | C1R | P00736 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775177 | 0.85 | MAPT (0.56) | TDP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL7422036 | 0.78 | HTR2B (0.44) | TDP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL15775344 | 0.73 | MAOA (0.57) | TDP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL15775643 | 0.73 | MAOB (0.46) | TDP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL26059158 | 0.71 | TDP1 (0.69) | TDP1ALDH1A1MAPTGAAGPR35 | |
| SCHEMBL15775299 | 0.71 | PARP1 (0.60) | TDP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL15775345 | 0.70 | ALDH1A1 (0.59) | TDP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL15775390 | 0.70 | TNKS (0.46) | TDP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3364130 | 0.70 | GPR35 (0.52) | TDP1ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL10725654 | 0.69 | MAPT (0.67) | TDP1ALDH1A1MAPTATMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| EP-1933622-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007109192-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |