Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | TNKS | O95271 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | KLK3 | P07288 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775344 | 0.87 | MAOA (0.57) | TNKSPARP1TNKS2PARP2TDP1 | |
| SCHEMBL15775390 | 0.86 | TNKS (0.46) | TNKSPARP1TNKS2PARP2TDP1 | |
| SCHEMBL15775345 | 0.86 | ALDH1A1 (0.59) | MAOBTNKSTDP1MEN1KMT2A | |
| SCHEMBL5067323 | 0.73 | TDP1 (0.49) | MAOBTDP1MEN1KMT2AKLK3 | |
| SCHEMBL15775461 | 0.73 | PARP1 (0.63) | TNKSPARP1TNKS2TDP1MAPT | |
| SCHEMBL28278178 | 0.72 | PTGES (0.75) | MAOBTNKSPARP1TNKS2PARP2 | |
| SCHEMBL5311674 | 0.69 | GABRP (0.56) | MAOBTNKSPARP1TNKS2PARP2 | |
| SCHEMBL8678891 | 0.69 | PTGES (0.60) | MAOBTNKSPARP1TNKS2PARP2 | |
| SCHEMBL15775177 | 0.68 | MAPT (0.56) | TDP1MEN1KMT2AKLK3MAPT | |
| SCHEMBL28276841 | 0.68 | PTGES (0.67) | TNKSPARP1TNKS2PARP2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |