Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525322 | 0.87 | NPC1 (0.59) | KDM4ENPC1RAB9AMEN1LMNA | |
| SCHEMBL15775402 | 0.86 | KDM4E (0.77) | KDM4ENPC1RAB9AMEN1LMNA | |
| SCHEMBL15775319 | 0.86 | KDM4E (0.59) | KDM4ENPC1RAB9AMEN1MAPT | |
| SCHEMBL15775601 | 0.84 | KDM4E (0.61) | KDM4ELMNAKMT2A | |
| SCHEMBL15775229 | 0.83 | KDM4E (0.57) | KDM4ENPC1RAB9AMEN1LMNA | |
| SCHEMBL15775437 | 0.83 | KDM4E (0.57) | KDM4ENPC1RAB9AMEN1KMT2A | |
| SCHEMBL1381716 | 0.83 | KDM4E (0.54) | KDM4ENPC1RAB9AMEN1LMNA | |
| SCHEMBL15775203 | 0.83 | TAS1R3 (0.47) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL13647658 | 0.82 | GAA (0.60) | KDM4ENPC1RAB9AMEN1LMNA | |
| SCHEMBL1381718 | 0.81 | ALDH1A1 (0.53) | KDM4ENPC1RAB9AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |