Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775319 | 0.88 | KDM4E (0.59) | KDM4EKMT2AMEN1MAPTPOLB | |
| SCHEMBL16383670 | 0.87 | KDM4E (1.00) | KDM4EKMT2AMEN1TSHRCYP1A2 | |
| SCHEMBL15775601 | 0.87 | KDM4E (0.61) | KDM4EKMT2APOLBLMNAKCNK3 | |
| SCHEMBL1815922 | 0.86 | KDM4E (0.77) | KDM4EKMT2AMEN1POLBLMNA | |
| SCHEMBL15775220 | 0.86 | KDM4E (0.58) | KDM4EKMT2AMEN1TP53MAPT | |
| SCHEMBL15775437 | 0.86 | KDM4E (0.57) | KDM4EKMT2AMEN1TP53POLB | |
| SCHEMBL15775229 | 0.86 | KDM4E (0.57) | KDM4EKMT2AMEN1CYP2D6CYP2C19 | |
| SCHEMBL15775332 | 0.83 | ALDH1A1 (0.55) | KDM4EKMT2AMEN1TP53MAPT | |
| SCHEMBL167021 | 0.83 | SMN1; SMN2 (0.57) | KDM4EKMT2AMEN1TSHRTP53 | |
| SCHEMBL15775205 | 0.81 | RORC (0.54) | KDM4EKMT2AMEN1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |