Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775601 | 0.89 | KDM4E (0.61) | KDM4EPOLBPDCD1CD274ALDH1A1 | |
| SCHEMBL15775437 | 0.88 | KDM4E (0.57) | KDM4ES1PR4POLBNPC1RAB9A | |
| SCHEMBL15775402 | 0.88 | KDM4E (0.77) | KDM4ES1PR4POLBNPC1RAB9A | |
| SCHEMBL15775229 | 0.88 | KDM4E (0.57) | KDM4ES1PR4POLBNPC1RAB9A | |
| SCHEMBL15775332 | 0.86 | ALDH1A1 (0.55) | KDM4EPOLBNPC1RAB9AMAPT | |
| SCHEMBL15775220 | 0.86 | KDM4E (0.58) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9523014 | 0.85 | S1PR4 (0.69) | KDM4ES1PR4POLBNPC1RAB9A | |
| SCHEMBL15775205 | 0.84 | RORC (0.54) | KDM4EPOLBNPC1RAB9AMAPT | |
| SCHEMBL15775208 | 0.83 | RAB9A (0.58) | KDM4ENPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL9522953 | 0.82 | S1PR4 (0.56) | KDM4ES1PR4POLBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |