Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.54 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13647658 | 0.91 | GAA (0.60) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL15775220 | 0.87 | KDM4E (0.58) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL31465682 | 0.86 | CES2 (0.53) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL7301820 | 0.85 | SMN1; SMN2 (0.61) | NPC1RAB9ALMNAMAPTKDM4E | |
| SCHEMBL1381716 | 0.84 | KDM4E (0.54) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL1815922 | 0.83 | KDM4E (0.77) | NPC1RAB9AMEN1LMNAKMT2A | |
| SCHEMBL3924697 | 0.83 | GAA (0.62) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL9523014 | 0.82 | S1PR4 (0.69) | NPC1RAB9AMAPTKMT2AKDM4E | |
| SCHEMBL13885541 | 0.82 | GAA (0.74) | NPC1RAB9AMEN1LMNAMAPT | |
| SCHEMBL1381718 | 0.82 | ALDH1A1 (0.53) | NPC1RAB9AMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0279633-B1 | ANTICONVULSANT AGENTS | ELI LILLY AND COMPANY (US) | 1993-04-07 | — | — | EP | disclosed |
| US-4981866-A | BENZAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1991-01-01 | — | — | US | disclosed |
| US-4939163-A | 4-substituted benzamide derivatives | ELI LILLY AND COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| US-4835181-A | Anticonvulsant agents using cyano dimethylphenyl benzamides | ELI LILLY AND COMPANY (US) | 1989-05-30 | — | — | US | disclosed |
| EP-0279633-A2 | Anticonvulsant agents | ELI LILLY AND COMPANY (US) | 1988-08-24 | — | — | EP | disclosed |