Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775580 | 0.88 | ALDH1A1 (0.46) | TDP1ALDH1A1PIN1POLBKDM4E | |
| SCHEMBL15775156 | 0.83 | NR1I3 (0.48) | TDP1ALDH1A1PIN1POLBMEN1 | |
| SCHEMBL15775280 | 0.79 | ELANE (0.43) | TDP1ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL15775364 | 0.79 | ALDH1A1 (0.49) | TDP1ALDH1A1PIN1POLBHSP90AA1 | |
| SCHEMBL15776164 | 0.79 | SQOR (0.47) | TDP1ALDH1A1POLBLMNAMAPT | |
| SCHEMBL15775590 | 0.79 | NPC1 (0.49) | PIN1POLBKDM4ESMN1; SMN2LMNA | |
| SCHEMBL15775195 | 0.78 | HSP90AA1 (0.47) | ALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL15775106 | 0.78 | TDP1 (0.47) | TDP1ALDH1A1PIN1POLBKDM4E | |
| SCHEMBL15775312 | 0.76 | SQOR (0.44) | TDP1ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL15775543 | 0.76 | LMNA (0.45) | TDP1ALDH1A1POLBKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |