Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15776164 | 0.88 | SQOR (0.47) | POLBTDP1ALDH1A1MAPTLMNA | |
| SCHEMBL15775312 | 0.85 | SQOR (0.44) | POLBTDP1ALDH1A1MAPTKDM4E | |
| SCHEMBL15775543 | 0.85 | LMNA (0.45) | POLBTDP1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL15775590 | 0.83 | NPC1 (0.49) | POLBMAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL15775156 | 0.82 | NR1I3 (0.48) | POLBTDP1ALDH1A1MAPTLMNA | |
| SCHEMBL15775417 | 0.79 | LMNA (0.45) | POLBMAPTSMN1; SMN2KDM4ELMNA | |
| SCHEMBL15775231 | 0.79 | SQOR (0.43) | POLBTDP1ALDH1A1MAPTMEN1 | |
| SCHEMBL15775322 | 0.79 | TDP1 (0.41) | POLBTDP1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL15775389 | 0.78 | ESR1 (0.45) | POLBESR1ESR2ALDH1A1MAPT | |
| SCHEMBL15775364 | 0.78 | ALDH1A1 (0.49) | POLBTDP1ALDH1A1MAPTABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |