Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167021 | 0.88 | SMN1; SMN2 (0.57) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL15775208 | 0.88 | RAB9A (0.58) | LMNAKMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL7574902 | 0.88 | TP53 (0.55) | MEN1KMT2AMAPTALDH1A1F10 | |
| SCHEMBL7028467 | 0.88 | KCNK3 (0.59) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15775483 | 0.87 | ALDH1A1 (0.54) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15775203 | 0.85 | TAS1R3 (0.47) | LMNAMEN1KMT2AMAPTNPC1 | |
| SCHEMBL7570311 | 0.83 | KMT2A (0.54) | LMNAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL15775229 | 0.82 | KDM4E (0.57) | LMNAMEN1KMT2AALDH1A1F10 | |
| SCHEMBL10179323 | 0.80 | F10 (0.69) | MEN1KMT2AF10NPC1SMN1; SMN2 | |
| SCHEMBL7018503 | 0.79 | MAPK1 (0.51) | LMNAMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |