Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | F10 | P00742 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167021 | 0.89 | SMN1; SMN2 (0.57) | TP53RAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL15775208 | 0.89 | RAB9A (0.58) | RAB9ASMN1; SMN2ALDH1A1NPC1KMT2A | |
| SCHEMBL7028467 | 0.89 | KCNK3 (0.59) | RAB9ASMN1; SMN2ALDH1A1NPC1KMT2A | |
| SCHEMBL15775343 | 0.88 | LMNA (0.58) | SMN1; SMN2ALDH1A1NPC1KMT2AF10 | |
| SCHEMBL15775483 | 0.88 | ALDH1A1 (0.54) | TP53RAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL15775332 | 0.86 | ALDH1A1 (0.55) | TP53RAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL15775203 | 0.86 | TAS1R3 (0.47) | TP53RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL7570311 | 0.84 | KMT2A (0.54) | RAB9ASMN1; SMN2ALDH1A1NPC1KMT2A | |
| SCHEMBL21870513 | 0.82 | ALDH1A1 (0.59) | TP53RAB9ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7242479 | 0.81 | TP53 (0.69) | TP53RAB9ASMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |
| EP-0966476-B1 | Quinazolinone compounds | UNIV NEWCASTLE VENTURES LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| US-6156739-A | Quinazolinone compounds | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |
| EP-0966476-A1 | QUINAZOLINONE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998033802-A1 | QUINAZOLINONE COMPOUNDS | NEWCASTLE UNIVERSITY VENTURES LIMITED (GB) | 1998-08-06 | — | — | WO | disclosed |