Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775643 | 0.86 | MAOB (0.46) | ALDH1A1MAPTTDP1MAOBTNKS | |
| SCHEMBL15775344 | 0.84 | MAOA (0.57) | ALDH1A1MAPTHPGDSMN1; SMN2TDP1 | |
| SCHEMBL15775390 | 0.83 | TNKS (0.46) | ALDH1A1MAPTKDM4ETDP1TNKS | |
| SCHEMBL15775317 | 0.75 | PARP1 (0.65) | ALDH1A1MAPTKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL28045622 | 0.74 | KDM4E (1.00) | ALDH1A1MAPTKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL10132630 | 0.72 | TDP1 (0.43) | ALDH1A1HPGDSMN1; SMN2TDP1NPC1 | |
| SCHEMBL29164287 | 0.72 | TDP1 (0.60) | ALDH1A1MAPTKDM4ESMN1; SMN2TDP1 | |
| SCHEMBL12317586 | 0.72 | MAPT (0.61) | ALDH1A1MAPTKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL5067323 | 0.70 | TDP1 (0.49) | ALDH1A1MAPTTDP1LMNAMAOB | |
| SCHEMBL3936503 | 0.70 | MAOA (0.50) | ALDH1A1MAPTKDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |