Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | UGCG | Q16739 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775204 | 0.89 | CYP19A1 (0.41) | ACHECYP19A1CA1CA2CA4 | |
| SCHEMBL15776282 | 0.88 | CYP19A1 (0.41) | ACHECYP19A1CA1CA2CA4 | |
| SCHEMBL15775961 | 0.84 | SMN1; SMN2 (0.46) | ACHECYP19A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL15775397 | 0.81 | ACHE (0.40) | ACHENPC1KDM4EMAPTPKM | |
| SCHEMBL15775467 | 0.78 | ALDH1A1 (0.36) | NPC1KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL15775307 | 0.78 | UGCG (0.41) | ACHEKDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL15775298 | 0.78 | ALDH1A1 (0.38) | CYP19A1NPC1MAPTPKMRAB9A | |
| SCHEMBL15775665 | 0.78 | ALDH1A1 (0.40) | NPC1KDM4EMAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL15775497 | 0.77 | UGCG (0.40) | ACHEKDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL15775739 | 0.75 | TNKS (0.40) | NPC1KDM4EMAPTPKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | claimed |
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |