Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.68 |
| ▸ | MMP9 | P14780 | 4/20 | 0.68 |
| ▸ | MMP8 | P22894 | 4/20 | 0.68 |
| ▸ | TNKS | O95271 | 4/20 | 0.63 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.63 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.63 |
| ▸ | GUSB | P08236 | 1/20 | 0.63 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.63 |
| ▸ | IDO1 | P14902 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 4/20 | 0.56 |
| ▸ | MMP13 | P45452 | 3/20 | 0.56 |
| ▸ | CASP3 | P42574 | 2/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.56 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.56 |
| ▸ | NPBWR1 | P48145 | 5/20 | 0.54 |
| ▸ | PARP1 | P09874 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618963 | 0.86 | ALDH1A1 (0.56) | MMP2MMP9MMP8TNKSTNKS2 | |
| SCHEMBL2823766 | 0.81 | ALDH1A1 (0.64) | TNKSTNKS2MAPTNPC1RAB9A | |
| SCHEMBL5010434 | 0.81 | MMP2 (1.00) | MMP2MMP9MMP8TNKSTNKS2 | |
| SCHEMBL15775687 | 0.79 | TNKS (0.59) | TNKSTNKS2MAPTNPC1RAB9A | |
| SCHEMBL15775265 | 0.79 | MAPT (0.68) | MMP2MMP9MMP8TNKSTNKS2 | |
| SCHEMBL8618978 | 0.79 | KDM4E (0.61) | TNKSTNKS2PARP2MAPTNPC1 | |
| SCHEMBL10628275 | 0.79 | ALDH1A1 (0.61) | MMP2MMP9MMP8TNKSTNKS2 | |
| SCHEMBL8618923 | 0.79 | TNKS (0.59) | TNKSTNKS2PARP2GUSBIDO1 | |
| SCHEMBL15775875 | 0.79 | ALDH1A1 (0.49) | MMP2MMP9MMP8TNKSTNKS2 | |
| SCHEMBL15775502 | 0.79 | PARP1 (0.59) | TNKSTNKS2GUSBMAPTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |