Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 4/20 | 0.44 |
| ▸ | TNKS | O95271 | 3/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | GCGR | P47871 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775256 | 0.88 | ACHE (0.49) | AURKAALDH1A1NPC1RAB9APKM | |
| SCHEMBL15775687 | 0.80 | TNKS (0.59) | ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL16331618 | 0.78 | ALDH1A1 (0.71) | AURKAALDH1A1NPC1RAB9APKM | |
| SCHEMBL31338639 | 0.78 | PARP1 (0.49) | AURKAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL15775362 | 0.77 | KDM4C (0.74) | ALDH1A1RAB9AKDM4ESMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL7280780 | 0.74 | NPC1 (0.56) | AURKAALDH1A1NPC1RAB9APKM | |
| SCHEMBL15775972 | 0.73 | TNKS (0.51) | AURKAALDH1A1NPC1RAB9APARP1 | |
| SCHEMBL15775258 | 0.73 | TNKS (0.67) | ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL15775257 | 0.73 | ALDH1A1 (0.60) | ALDH1A1NPC1RAB9APKMKDM4E | |
| SCHEMBL15775281 | 0.73 | KDM4C (0.56) | ALDH1A1NPC1RAB9AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |