Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 2/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.36 |
| ▸ | PPIB | P23284 | 1/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.35 |
| ▸ | PPID | Q08752 | 1/20 | 0.35 |
| ▸ | PPIG | Q13427 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1579330 | 0.81 | ALDH1A1 (0.45) | GPR119SMN1; SMN2 | |
| SCHEMBL545381 | 0.80 | KDM4A (0.43) | AKR1B1EPHX2NR1H4 | |
| SCHEMBL27841982 | 0.80 | GPR119 (0.38) | GPR119ANO1EPHX2NR1H4MAPK8 | |
| SCHEMBL1578865 | 0.80 | ALDH1A1 (0.42) | GPR119MTNR1AMTNR1BSMN1; SMN2PTPRC | |
| SCHEMBL1579091 | 0.79 | GPR119 (0.40) | GPR119MTNR1AMTNR1BSMN1; SMN2ANO1 | |
| SCHEMBL3694006 | 0.79 | MTNR1A (0.39) | MTNR1AMTNR1B | |
| SCHEMBL1578976 | 0.78 | PPIB (0.46) | PTPRCPPIBPPIAPPIDPPIG | |
| SCHEMBL31444666 | 0.76 | MAPK8 (0.41) | AKR1B1ANO1MAPK8 | |
| SCHEMBL23713473 | 0.76 | GAA (0.44) | — | |
| SCHEMBL31156791 | 0.75 | NQO2 (0.49) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310357-B1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL AVIV UNIV LIMITED (IL) | 2019-09-11 | — | — | EP | disclosed |
| US-9675567-B2 | Potassium ion channel modulators and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2017-06-13 | — | — | US | disclosed |
| US-20160374969-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-12-29 | — | — | US | disclosed |
| US-9464052-B2 | Potassium ion channel modulators and uses thereof | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2016-10-11 | — | — | US | disclosed |
| US-20110245250-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2011-10-06 | — | — | US | disclosed |
| EP-2310357-A1 | POTASSIUM ION CHANNEL MODULATORS&USES THEREOF | Ramot at Tel Aviv University Limited (IL) | 2011-04-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245250-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | SCN1B, KCNN3, SCN2B | GPR119 279/4885MTNR1A 186/4885MTNR1B 160/4885 |
| US-20160374969-A1 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF | KCNJ11, KCNJ1, KCNJ2 | GPR119 493/4885MTNR1A 607/4885MTNR1B 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.