SCHEMBL158041

SCHEMBL158041

CC(C)C(C(=O)O)N1C(=O)C(=Cc2ccc(Br)cc2)SC1=S

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 8/20 1.00
MEN1 O00255 5/20 1.00
KMT2A Q03164 5/20 1.00
MCL1 Q07820 2/20 1.00
BCL2L1 Q07817 1/20 1.00
BAK1 Q16611 1/20 1.00
BCL2L2 Q92843 7/20 0.73
BAD Q92934 1/20 0.64
MAPT P10636 4/20 0.64
ADAMTS5 Q9UNA0 2/20 0.61
POLB P06746 3/20 0.60
ALDH1A1 P00352 2/20 0.60
LMNA P02545 1/20 0.60
GAA P10253 1/20 0.60
KDM4E B2RXH2 1/20 0.53
USP2 O75604 1/20 0.53
CYP3A4 P08684 1/20 0.53
THRB P10828 1/20 0.53
CYP2C9 P11712 1/20 0.53
HPGD P15428 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4264548 1.00 BCL2 (1.00) BCL2MEN1KMT2AMCL1BCL2L1
SCHEMBL158040 1.00 BCL2 (1.00) BCL2MEN1KMT2AMCL1BCL2L1
SCHEMBL13812532 0.89 BCL2 (0.80) BCL2MEN1KMT2AMCL1BCL2L1
SCHEMBL13982547 0.89 BCL2 (0.80) BCL2MEN1KMT2AMCL1BCL2L1
SCHEMBL5970105 0.89 BCL2 (0.80) BCL2MEN1KMT2AMCL1BCL2L1
SCHEMBL5970104 0.89 BCL2 (0.80) BCL2MEN1KMT2AMCL1BCL2L1
SCHEMBL14163443 0.88 KMT2A (0.78) BCL2MEN1KMT2AMCL1BCL2L1
SCHEMBL13657863 0.87 BCL2 (0.77) BCL2MEN1KMT2AMCL1BCL2L1
SCHEMBL3426372 0.87 BCL2 (0.76) BCL2MEN1KMT2AMCL1BCL2L1
SCHEMBL3426376 0.87 BCL2 (0.76) BCL2MEN1KMT2AMCL1BCL2L1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4486761-A1 MODIFICATION OF BRASSINOSTEROID RECEPTOR GENES TO IMPROVE YIELD TRAITS Pairwise Plants Services, Inc. (US) 2025-01-08 EP claimed
CN-119072487-A Modification of brassinosteroid receptor gene for improving yield traits 成对植物服务股份有限公司 2024-12-03 CN claimed
US-20240327858-A1 MODIFICATION OF BRASSINOSTEROID RECEPTOR GENES TO IMPROVE YIELD TRAITS PAIRWISE PLANTS SERVICES, INC. 2024-10-03 US claimed
WO-2023168217-A1 MODIFICATION OF BRASSINOSTEROID RECEPTOR GENES TO IMPROVE YIELD TRAITS PAIRWISE PLANTS SERVICES, INC. (US) 2023-09-07 WO claimed
US-9426992-B1 Method for inhibiting conidial germination and mycelial growth of fungi symbiotically associated with bark beetles Montana State University—Billings (US) 2016-08-30 US claimed
US-RE43615-E1 Method for controlling the yeast-to-filamentous growth transition in fungi Montana State University—Billings (US) 2012-08-28 US claimed
US-7825143-B2 contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit the yeast-to-filamentous growth transition, wherein the anti-fungal small molecule is 5-(p-bromobenzylidine)- alpha -isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid MONTANA STATE UNIVERSITY - BILLINGS (US) 2010-11-02 US claimed
US-20090018173-A1 Method for controlling the yeast-to-filamentous growth transition in fungi MONTANA STATE UNIVERSITY - BILLINGS (US) 2009-01-15 US claimed
US-20260027162-A1 MUCISPIRILLUM COMPOSITIONS AND CANCER TREATMENT METHODS THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2026-01-29 US disclosed
WO-2025262113-A1 COMBINATION THERAPY USING MALT1 AND BCL-2 INHIBITORS AND METHODS OF REDUCING REGULATORY T CELLS JANSSEN PHARMACEUTICA NV (BE) 2025-12-26 WO disclosed
US-20250270536-A1 BACTERIAL COMPOSITIONS AND METHODS FOR GROWING BACTERIA ON PARTICLES MYBIOTICS PHARMA LTD. (IL) 2025-08-28 US disclosed
EP-4555326-A2 MUCISPIRILLUM COMPOSITIONS AND CANCER TREATMENT METHODS THEREOF President And Fellows Of Harvard College (US) 2025-05-21 EP disclosed
CN-119894525-A Mucispirillum compositions and methods of treating cancer 哈佛大学校长及研究员协会 2025-04-25 CN disclosed
EP-4514368-A1 BACTERIAL COMPOSITIONS AND METHODS FOR GROWING BACTERIA ON PARTICLES Mybiotics Pharma Ltd (IL) 2025-03-05 EP disclosed
US-7825143-B2 contacting a fungal cell with an anti-fungal small molecule in an amount effective to reduce or inhibit the yeast-to-filamentous growth transition, wherein the anti-fungal small molecule is 5-(p-bromobenzylidine)- alpha -isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid MONTANA STATE UNIVERSITY - BILLINGS (US) 2010-11-02 US disclosed
US-20090069324-A1 CHEMICAL INHIBITORS OF BFL-1 AND RELATED METHODS THE BURNHAM INSTITUTE (US) 2009-03-12 US disclosed
US-20090048168-A1 INHIBITORS OF BCL-2 NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2009-02-19 US disclosed
US-20090018173-A1 Method for controlling the yeast-to-filamentous growth transition in fungi MONTANA STATE UNIVERSITY - BILLINGS (US) 2009-01-15 US disclosed
US-20090018173-A1 Method for controlling the yeast-to-filamentous growth transition in fungi MONTANA STATE UNIVERSITY - BILLINGS (US) 2009-01-15 US disclosed
WO-2008157003-A2 CHEMICAL INHIBITORS OF BFL-1 AND RELATED METHODS THE BURNHAM INSTITUTE (US) 2008-12-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260027162-A1 MUCISPIRILLUM COMPOSITIONS AND CANCER TREATMENT METHODS THEREOF SAAL1, CD74, MUC1 BCL2 3415/4885MEN1 301/4885KMT2A 3742/4885
US-20090018173-A1 Method for controlling the yeast-to-filamentous growth transition in fungi ERG28, MANBA, TALDO1 BCL2 4182/4885MEN1 2818/4885KMT2A 2469/4885
US-20090048168-A1 INHIBITORS OF BCL-2 BCLAF1, BID, BCL2L1 BCL2 6/4885MEN1 2843/4885KMT2A 2267/4885
US-20090069324-A1 CHEMICAL INHIBITORS OF BFL-1 AND RELATED METHODS TMBIM6, BCL2L1, BCL2L11 BCL2 15/4885MEN1 1821/4885KMT2A 3876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.