Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.54 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397141 | 0.93 | KIF11 (0.61) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL7719106 | 0.91 | PDE3B (0.46) | KIF11PDE3BPDE3AMAOBMAOA | |
| SCHEMBL17630052 | 0.91 | PDE3B (0.46) | KIF11PDE3BPDE3AMAOBMAOA | |
| SCHEMBL18499494 | 0.86 | KIF11 (0.54) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL19308493 | 0.86 | KIF11 (0.54) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL27806612 | 0.85 | KIF11 (0.51) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL91992 | 0.85 | ALDH1A1 (0.53) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL15834317 | 0.85 | MMP3 (0.63) | KIF11PDE3BPDE3APDK2MMP3 | |
| SCHEMBL91862 | 0.85 | ALDH1A1 (0.53) | KIF11PDE3BPDE3ACYP11B1CYP11B2 | |
| SCHEMBL1773406 | 0.81 | MAOB (0.64) | KIF11MAOBMAOACYP11B2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935512-B1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2018-12-26 | — | — | EP | disclosed |
| US-20150323722-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2015-11-12 | — | — | US | disclosed |
| US-20150323722-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2015-11-12 | — | — | US | disclosed |
| US-20150323722-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2015-11-12 | — | — | US | disclosed |
| WO-2014094949-A1 | REACTIVE MESOGENS | MERCK PATENT GMBH (DE) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150323722-A1 | REACTIVE MESOGENS | BLM, MAFG, MCRS1 | KIF11 811/4885PDE3B 4351/4885PDE3A 4152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.